Document Detail

Effect of buccal administration of a lactose-containing nitroglycerin tablet (Suscard) on plaque pH.
MedLine Citation:
PMID:  7871354     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to monitor pH in 2-day-old dental plaque after administration of a long-acting, lactose-containing nitroglycerin tablet (Suscard). The tablet was placed under the lip of the maxilla. This was done both in two older subjects suffering from heart problems and in 10 younger, healthy subjects. In the latter group, a sucrose-containing lozenge was used as a control. The influence of a 5-wk period of daily use of Suscard (in the two elderly subjects) and the effect of normal oral hygiene procedures (in the 10 younger subjects) on the pH response was also studied. Plaque pH was measured in situ up to 1 h, at five different approximal sites in the front region of the maxilla by the micro-touch method. The Suscard tablet resulted in a fall in plaque pH in both groups when teeth had not been brushed for 2 days. The lowest pH was recorded at the sites close to where the tablet had been placed. The most attenuated pH drop was found in the two older subjects, who showed a mean minimum pH of 5.7, as compared with 6.2 for the younger subjects. No further increase in the pH fall from Suscard was seen after the 5-wk period in the two patients with heart problems. In the 10 younger healthy subjects, the most pronounced pH decrease was registered after administration of the sucrose-containing lozenge. The pH drop for Suscard was not significant when normal oral hygiene procedures preceded the test.(ABSTRACT TRUNCATED AT 250 WORDS)
P Lingström; D Birkhed
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Scandinavian journal of dental research     Volume:  102     ISSN:  0029-845X     ISO Abbreviation:  Scand J Dent Res     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-03-30     Completed Date:  1995-03-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0270023     Medline TA:  Scand J Dent Res     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  324-8     Citation Subset:  D; IM    
Department of Cariology, Faculty of Odontology, Göteborg University, Sweden.
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MeSH Terms
Administration, Buccal
Delayed-Action Preparations
Dental Plaque / physiopathology*
Hydrogen-Ion Concentration
Lactose / administration & dosage,  pharmacology*
Middle Aged
Nitroglycerin / administration & dosage*
Oral Hygiene
Pharmaceutic Aids
Sucrose / pharmacology
Time Factors
Reg. No./Substance:
0/Delayed-Action Preparations; 0/Pharmaceutic Aids; 0/Tablets; 55-63-0/Nitroglycerin; 57-50-1/Sucrose; 63-42-3/Lactose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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