Document Detail

Effect of bronchodilators on airway resistance in ventilator-dependent neonates with chronic lung disease.
MedLine Citation:
PMID:  2956405     Owner:  NLM     Status:  MEDLINE    
Using a noninvasive passive flow volume technique to measure respiratory system resistance (Rrs) and compliance (Crs), the effects of two inhaled bronchodilators, salbutamol (beta 2-agonist) and ipratropium bromide (muscarinic blocker), were studied in 17 premature infants ranging in age from 19 to 103 days. All were ventilator dependent with chronic lung disease. The pretreatment Rrs was high (range 0.15 to 0.27 cm H2O X ml-1 X sec). After administration of salbutamol, the mean group Rrs decreased 24% +/- 11% (mean +/- SD), and Crs increased significantly, 17% +/- 21%. The response to ipratropium bromide in five infants did not differ significantly from their responses to salbutamol. Nebulized saline solution had no bronchodilator effect in five infants. These results suggest that in infants with early and late chronic lung disease, bronchospasm can be partially alleviated by inhaled bronchodilators.
R A Wilkie; M H Bryan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  111     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-09-10     Completed Date:  1987-09-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  278-82     Citation Subset:  AIM; IM    
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MeSH Terms
Airway Resistance / drug effects*
Albuterol / therapeutic use
Bronchodilator Agents / therapeutic use*
Bronchopulmonary Dysplasia / drug therapy*,  physiopathology
Chronic Disease
Drug Evaluation
Infant, Newborn
Infant, Premature
Ipratropium / therapeutic use
Lung Compliance / drug effects
Nebulizers and Vaporizers
Ventilators, Mechanical*
Reg. No./Substance:
0/Bronchodilator Agents; 18559-94-9/Albuterol; 60205-81-4/Ipratropium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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