Document Detail

Effect of broad and narrow spectrum fluorescent light on blood constituents.
MedLine Citation:
PMID:  953178     Owner:  NLM     Status:  MEDLINE    
Riboflavin in whole blood, G-6-PD activity in erythrocytes and amino acids in plasma of infants irradiated by broad and narrow spectrum blue fluorescent light were determined. Riboflavin was reduced by both types of light. Loss of G-6-PD activity during phototherapy with subsequent hemolysis was observed in some infants under each type of light source, both in vivo and in vitro. This phenomenon may be related to the indirect effect of riboflavin reduction and not to a direct effect upon the enzyme. The reduction of the plasma concentration of some amino acids observed under broad spectrum irradiation but not under pure blue light may not be of significance, but is of concern. These data indicate that all fluorescent light sources in current use for phototherapy produce biologic effects of importance beside the primary purpose of the treatment to reduce hyperbilirubinemia. It is apparent from the results of these studies that phototherapy light penetrates more deeply than the superficial skin to exert photochemical effects.
T R Sisson; B Slaven; P B Hamilton
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Birth defects original article series     Volume:  12     ISSN:  0547-6844     ISO Abbreviation:  Birth Defects Orig. Artic. Ser.     Publication Date:  1976  
Date Detail:
Created Date:  1976-10-20     Completed Date:  1976-10-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0003403     Medline TA:  Birth Defects Orig Artic Ser     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  122-33     Citation Subset:  IM    
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MeSH Terms
Amino Acids / blood
Bilirubin / metabolism
Blood* / radiation effects
Erythrocytes / enzymology
Glucosephosphate Dehydrogenase / blood
Infant, Newborn
Jaundice, Neonatal / therapy
Radiation Effects
Riboflavin / blood
Spectrometry, Fluorescence
Reg. No./Substance:
0/Amino Acids; 635-65-4/Bilirubin; 83-88-5/Riboflavin; EC Dehydrogenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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