Document Detail


Effect of brimonidine tartrate 0.15% on night-vision difficulty and contrast testing after refractive surgery.
MedLine Citation:
PMID:  18721716     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To evaluate the efficacy of brimonidine tartrate ophthalmic solution 0.15% in patients with night-vision difficulties after laser refractive surgery. SETTING: Center for Refractive Surgery, Walter Reed Army Medical Center, Washington, District of Columbia, USA. METHODS: Six patients with significant night-vision complaints after refractive surgery were enrolled in this study after other treatable causes of night-vision difficulty such as residual refractive error and dry eye were excluded. Low-contrast visual acuity (LCVA) over a range of contrasts (1.25% to 25%) and small letter contrast sensitivity were tested at photopic (100 cd/m(2)) and mesopic (1 cd/m(2)) luminance levels, with and without a standard glare source. Testing was performed before brimonidine tartrate ophthalmic solution 0.15% was administered. Measurements were repeated 1 hour and 1 month after the use of brimonidine tartrate. RESULTS: One hour after using brimonidine tartrate 0.15% solution, patients had significant improvement in LCVA, LCVA with glare, and contrast sensitivity. After 1 month of treatment, all 6 patients reported subjective improvement in night vision and there was a significant difference in performance in mesopic LCVA and mesopic LCVA with glare. The mean pupil size before administration of brimonidine tartrate ophthalmic solution 0.15% was 6.44 mm +/- 1.11 (SD). Pupil size 1 hour after instillation had decreased to 4.53 +/- 1.27 mm and at 1 month had increased to 6.50 +/- 0.94 mm. CONCLUSION: Brimonidine tartrate ophthalmic solution 0.15% improved contrast sensitivity and acuity and decreased night-vision difficulty for up to 1 month in patients with significant complaints after refractive surgery.
Authors:
Jayson D Edwards; Jenna M Burka; Kraig S Bower; Richard D Stutzman; Denise A Sediq; Jeff C Rabin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cataract and refractive surgery     Volume:  34     ISSN:  0886-3350     ISO Abbreviation:  J Cataract Refract Surg     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-25     Completed Date:  2008-10-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8604171     Medline TA:  J Cataract Refract Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1538-41     Citation Subset:  IM    
Affiliation:
Ophthalmology Service, Walter Reed Army Medical Center, 6900 Georgia Avenue NW, Washington, DC 20307, USA. jayson.edwards@amedd.army.mil
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MeSH Terms
Descriptor/Qualifier:
Adrenergic alpha-Agonists / administration & dosage*
Adult
Contrast Sensitivity / drug effects*,  physiology
Humans
Keratomileusis, Laser In Situ
Lasers, Excimer
Male
Middle Aged
Military Personnel
Night Blindness / drug therapy*,  etiology,  physiopathology
Ophthalmic Solutions / administration & dosage*
Photorefractive Keratectomy
Postoperative Complications*
Prospective Studies
Pupil / drug effects
Questionnaires
Quinoxalines / administration & dosage*
Visual Acuity
Chemical
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Ophthalmic Solutions; 0/Quinoxalines; 59803-98-4/brimonidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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