| Effect of brimonidine tartrate 0.15% on night-vision difficulty and contrast testing after refractive surgery. | |
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MedLine Citation:
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PMID: 18721716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the efficacy of brimonidine tartrate ophthalmic solution 0.15% in patients with night-vision difficulties after laser refractive surgery. SETTING: Center for Refractive Surgery, Walter Reed Army Medical Center, Washington, District of Columbia, USA. METHODS: Six patients with significant night-vision complaints after refractive surgery were enrolled in this study after other treatable causes of night-vision difficulty such as residual refractive error and dry eye were excluded. Low-contrast visual acuity (LCVA) over a range of contrasts (1.25% to 25%) and small letter contrast sensitivity were tested at photopic (100 cd/m(2)) and mesopic (1 cd/m(2)) luminance levels, with and without a standard glare source. Testing was performed before brimonidine tartrate ophthalmic solution 0.15% was administered. Measurements were repeated 1 hour and 1 month after the use of brimonidine tartrate. RESULTS: One hour after using brimonidine tartrate 0.15% solution, patients had significant improvement in LCVA, LCVA with glare, and contrast sensitivity. After 1 month of treatment, all 6 patients reported subjective improvement in night vision and there was a significant difference in performance in mesopic LCVA and mesopic LCVA with glare. The mean pupil size before administration of brimonidine tartrate ophthalmic solution 0.15% was 6.44 mm +/- 1.11 (SD). Pupil size 1 hour after instillation had decreased to 4.53 +/- 1.27 mm and at 1 month had increased to 6.50 +/- 0.94 mm. CONCLUSION: Brimonidine tartrate ophthalmic solution 0.15% improved contrast sensitivity and acuity and decreased night-vision difficulty for up to 1 month in patients with significant complaints after refractive surgery. |
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Authors:
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Jayson D Edwards; Jenna M Burka; Kraig S Bower; Richard D Stutzman; Denise A Sediq; Jeff C Rabin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cataract and refractive surgery Volume: 34 ISSN: 0886-3350 ISO Abbreviation: J Cataract Refract Surg Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-08-25 Completed Date: 2008-10-03 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8604171 Medline TA: J Cataract Refract Surg Country: United States |
Other Details:
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Languages: eng Pagination: 1538-41 Citation Subset: IM |
Affiliation:
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Ophthalmology Service, Walter Reed Army Medical Center, 6900 Georgia Avenue NW, Washington, DC 20307, USA. jayson.edwards@amedd.army.mil |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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administration & dosage* Adult Contrast Sensitivity / drug effects*, physiology Humans Keratomileusis, Laser In Situ Lasers, Excimer Male Middle Aged Military Personnel Night Blindness / drug therapy*, etiology, physiopathology Ophthalmic Solutions / administration & dosage* Photorefractive Keratectomy Postoperative Complications* Prospective Studies Pupil / drug effects Questionnaires Quinoxalines / administration & dosage* Visual Acuity |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Ophthalmic Solutions; 0/Quinoxalines; 59803-98-4/brimonidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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