| Effect of brief periods of paced ventricular tachycardia on coronary blood flow in dogs before and after graded coronary stenosis. | |
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MedLine Citation:
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PMID: 6847587 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effect of short bouts (1 min) of electrically induced ventricular tachycardias (VT) of increasing rates (160-240/min) was studied in 8 anesthetized dogs before and after graded constrictions of the left anterior descending (LAD) and the circumflex (CCA) coronary arteries. In the absence of coronary stenosis, paroxysmal VT caused a significant decrease in tension-time index (TTI), coronary blood flow (CBF) and coronary vascular resistance (CVR). Single and combined coronary stenosis caused relatively small alterations of the VT-induced depression of the systemic hemodynamics but reversed the effect of paroxysmal VT on the CVR. In the presence of single 90% LAD stenosis, VT resulted in an increase in CVR-LAD and a decrease in F-LAD associated with a fall in CVR-CCA and a rise in F-CCA. Combination of 90% LAD plus 70% CCA stenosis abolished the compensatory fall of CVR-CCA resulting in a pronounced reduction of F-CCA during VT. The results support the concept that in the presence of severe coronary stenosis brief paroxysmal ventricular tachycardias do increase myocardial nutritional demand but rather decrease nutritional supply. |
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Authors:
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J Senges; U Mittmann; I Rizos; J Brachmann; L Beck; H D Hammann; W Braun; W Kübler |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Basic research in cardiology Volume: 78 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 1983 Jan-Feb |
Date Detail:
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Created Date: 1983-06-10 Completed Date: 1983-06-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 99-111 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiac Pacing, Artificial Coronary Circulation* Coronary Disease / physiopathology* Dogs Female Heart Rate Hemodynamics* Male Tachycardia / physiopathology* Vascular Resistance |
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