Document Detail

Effect of breathing low concentrations of volatile anaesthetic agents on incidence of adverse airway events.
MedLine Citation:
PMID:  16179038     Owner:  NLM     Status:  MEDLINE    
The effect of breathing 0.1 minimum alveolar concentrations (MAC) of desflurane or isoflurane for three minutes on the incidence of adverse airway events on a subsequent breath of 2 MAC was investigated. Twenty-five volunteers known to develop an adverse airway event to desflurane or isoflurane took part in the study. Each volunteer was exposed to isoflurane and desflurane at least 24 h apart. Volunteers were assessed for adverse airway events while breathing 2 MAC inhalational anaesthetic following breathing 100% O(2) for 3 min. This was repeated with 0.1 MAC inhalational anaesthetic in oxygen instead of 100% O(2). Adverse airway events decreased from 88% to 40% when tests were conducted with desflurane (p = 0.002). With isoflurane, the reduction from 60% to 52% was not statistically significant (p = 0.774). Breathing low concentrations of desflurane decreases the incidence of adverse airway events on subsequent inhalation of higher concentration of desflurane.
N Goodwin; P J Strong; G Sudhir; A R Wilkes; J E Hall
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia     Volume:  60     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-23     Completed Date:  2005-10-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  955-9     Citation Subset:  AIM; IM    
University Hospital of Wales, Heath Park, Cardiff CF14 4XN, Wales, UK.
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MeSH Terms
Anesthetics, Inhalation / administration & dosage,  adverse effects*
Cough / chemically induced
Cross-Over Studies
Drug Administration Schedule
Intraoperative Complications / chemically induced*
Isoflurane / administration & dosage,  adverse effects*,  analogs & derivatives*
Respiration Disorders / chemically induced
Salivation / drug effects
Single-Blind Method
Reg. No./Substance:
0/Anesthetics, Inhalation; 26675-46-7/Isoflurane; 57041-67-5/desflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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