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Effect of branched-chain amino acid supplementation on the oxidized/reduced state of plasma albumin in rats with chronic liver disease.
MedLine Citation:
PMID:  22247603     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
We examined whether continuous supplementation with branched-chain amino acids phosphorylates ribosomal protein S6, a downstream effector of mammalian target of rapamycin, and improves hypoalbuminemia of rats with chronic liver disease. Sprague-Dawley rats were fed a casein diet (control group) or a branched-chain amino acid-supplemented casein diet (branched-chain amino acid group) for 11 weeks with repeated injections of carbon tetrachloride. Throughout this experimental period, no significant difference in plasma albumin concentration was seen between groups. The percentage of reduced albumin within total plasma albumin gradually decreased in both control and branched-chain amino acid groups. After 11 weeks with supplementation, phosphorylation of ribosomal protein S6 was significantly increased in the liver of rats in the branched-chain amino acid group compared with the control group. Furthermore, the percentage of reduced albumin within total albumin was significantly higher in the branched-chain amino acid group than in the control group. These results indicate that continuous supplementation with branched-chain amino acids in rats with chronic liver disease induces phosphorylation of hepatic ribosomal protein S6 and attenuates decreases in the percentage of reduced albumin, although levels of plasma albumin are not increased.
Authors:
Masashi Kuwahata; Hiroyo Kubota; Misaki Katsukawa; Shunsuke Ito; Aki Ogawa; Yukiko Kobayashi; Yasushi Nakamura; Yasuhiro Kido
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Publication Detail:
Type:  Journal Article     Date:  2011-09-03
Journal Detail:
Title:  Journal of clinical biochemistry and nutrition     Volume:  50     ISSN:  1880-5086     ISO Abbreviation:  J Clin Biochem Nutr     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-16     Completed Date:  2012-08-23     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  8700907     Medline TA:  J Clin Biochem Nutr     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  67-71     Citation Subset:  -    
Affiliation:
Departments of Nutrition Science, Kyoto Prefectural University, 1-5 Shimogamo-hangi-cho, Sakyo, Kyoto 606-8522, Japan.
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