| Effect of botulinum toxin A on the intraocular pressure and the retina in an animal model. | |
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MedLine Citation:
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PMID: 22917001 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: The purpose of our study was to investigate the effect of an inadvertent intravitreal injection of botulinum toxin A (BTA) on the intraocular pressure (IOP) and the retina in an animal model. Methods: BTA was injected intravitreally in normotensive rats. IOP was measured preoperatively as well as 1, 2, and 4 weeks postoperatively. Retinas were stained in vivo using a retrograde labelling technique and the density of retinal ganglion cells (RGCs) was determined. Immunohistochemistry was performed for rhodopsin and retinal glial fibrillary acidic protein (GFAP). Results: Significant temporary IOP elevation occurred in all groups in the immediate postoperative period (ANOVA, p < 0.05). IOP changes in the intermediate period were not statistically significant (ANOVA, p > 0.05). The differences in the density of RGCs after BTA injection were not statistically significant (ANOVA, p > 0.05). All retinas displayed the same immunostaining pattern for rhodopsin and GFAP. Conclusion: Our findings indicate that BTA has probably no severe impact on IOP and the retina after an inadvertent intravitreal injection. However, temporary rise of IOP may possibly occur in the immediate postoperative period due to a volume-effect. |
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Authors:
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Zisis Gatzioufas; Tobias Stupp; Marilita M Moschos; Konstantinos Kopsidas; Petar Charalambous; Solon Thanos |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-24 |
Journal Detail:
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Title: Cutaneous and ocular toxicology Volume: - ISSN: 1556-9535 ISO Abbreviation: Cutan Ocul Toxicol Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101266892 Medline TA: Cutan Ocul Toxicol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Institute of Experimental Ophthalmology, University of Muenster , Muenster , Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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