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Effect of the bone marrow cell transplantation on elevated plus-maze performance in hippocampal-injured mice.
MedLine Citation:
PMID:  23578758     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Several reports have shown that the hippocampus plays an important role in different aspects of the emotional control. There is evidence that lesions in this structure cause behavioural disinhibition, with reduction of reactions expressing fear and anxiety. Thus, to portray the aptitude of cell therapy to abrogate injuries of hippocampal tissue, we examined the behavioural effects of bone marrow mononuclear cells (BMMCs) transplantation on C57BL/6 mice that had the hippocampus damaged by electrolytic lesion. For this purpose, mice received, seven days after bilateral electrolytic lesion in the dorsal hippocampus, culture medium or BMMCs expressing the enhanced green fluorescent protein (EGFP) transgene. One week after transplantation, animals were tested in the elevated plus-maze (EPM). On the whole, three assessment sessions in the EPM were carried out, with seven days separating each trial. Thirty-five days after the induction of injury, mice were sacrificed and their brains removed for immunohistochemistry. The behavioural evaluation showed that the hippocampal lesion caused disinhibition, an effect which was slightly lessened, from the second EPM test, in transplanted subjects. On the other hand, immunohistochemical data revealed an insignificant presence of EGFP(+) cells inside the brains of injured mice. In view of such scenario, we hypothesised that the subtle rehabilitation of the altered behaviour might be a result from a paracrine effect from the transplanted cells. This might have been caused by the release of bioactive factors capable of boosting endogenous recuperative mechanisms for a partial regaining of the hippocampal functions.
Authors:
Luís Bruno da Cruz E Alves-de-Moraes; João Tadeu Ribeiro-Paes; Beatriz Monteiro Longo; Enéas Galdini Ferrazoli; Telma Gonçalves Carneiro Spera de Andrade
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-8
Journal Detail:
Title:  Behavioural brain research     Volume:  -     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier B.V.
Affiliation:
Post-Graduation in Biotechnology, USP/IPT/I. Butantan, Avenida Prof. Lineu Prestes 2415, Cidade Universitária, 05508-900, São Paulo, SP, Brazil.
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