| Effect of body position on ventilatory responses in anaesthetised mice. | |
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MedLine Citation:
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PMID: 15946877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of body position on ventilatory responses to chemical stimuli have rarely been studied in experimental animals, despite evidence that position may be a factor in respiratory results. The purpose of this study was to test whether body position could affect acute ventilatory responses to 4-min periods of moderate hypercapnia (5% CO(2) in O(2)) and poikilocapnic hypoxia (15% O(2) in N(2)) in the urethane-anaesthetised mouse. Respiratory measurements were conducted with mice in the prone and supine positions with a whole-body, single-chamber plethysmograph. During hypoxia, the time course of minute ventilation (V (E)) was similar in the two positions, but the breathing pattern was different. After the response peak, V (E) depended on respiratory frequency (f) and tidal volume (V(T)) in the prone position but mainly on V(T) in the supine position. In the supine position, f declined below the baseline values toward the end of hypoxic exposure. During hypercapnia, there were no ventilatory differences between the prone and supine positions. Brief hypoxic exposure elicited f depression in the supine position in the anaesthetised mouse. The depressive effect on f suggests that the supine position may not be optimal for sustaining ventilation, particularly during hypoxia. |
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Authors:
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Masahiko Izumizaki; Mieczyslaw Pokorski; Yohei Ishihara; Michiko Iwase; Ikuo Homma |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology Volume: 141 ISSN: 1095-6433 ISO Abbreviation: Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-07-18 Completed Date: 2005-09-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9806096 Medline TA: Comp Biochem Physiol A Mol Integr Physiol Country: United States |
Other Details:
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Languages: eng Pagination: 133-9 Citation Subset: IM |
Affiliation:
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Department of Physiology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia* Animals Anoxia / physiopathology Blood Gas Analysis Hypercapnia / physiopathology Male Mice Mice, Inbred C57BL Prone Position / physiology* Pulmonary Ventilation* Supine Position / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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