Document Detail

Effect of body position on ventilatory responses in anaesthetised mice.
MedLine Citation:
PMID:  15946877     Owner:  NLM     Status:  MEDLINE    
The effects of body position on ventilatory responses to chemical stimuli have rarely been studied in experimental animals, despite evidence that position may be a factor in respiratory results. The purpose of this study was to test whether body position could affect acute ventilatory responses to 4-min periods of moderate hypercapnia (5% CO(2) in O(2)) and poikilocapnic hypoxia (15% O(2) in N(2)) in the urethane-anaesthetised mouse. Respiratory measurements were conducted with mice in the prone and supine positions with a whole-body, single-chamber plethysmograph. During hypoxia, the time course of minute ventilation (V (E)) was similar in the two positions, but the breathing pattern was different. After the response peak, V (E) depended on respiratory frequency (f) and tidal volume (V(T)) in the prone position but mainly on V(T) in the supine position. In the supine position, f declined below the baseline values toward the end of hypoxic exposure. During hypercapnia, there were no ventilatory differences between the prone and supine positions. Brief hypoxic exposure elicited f depression in the supine position in the anaesthetised mouse. The depressive effect on f suggests that the supine position may not be optimal for sustaining ventilation, particularly during hypoxia.
Masahiko Izumizaki; Mieczyslaw Pokorski; Yohei Ishihara; Michiko Iwase; Ikuo Homma
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology     Volume:  141     ISSN:  1095-6433     ISO Abbreviation:  Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-07-18     Completed Date:  2005-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9806096     Medline TA:  Comp Biochem Physiol A Mol Integr Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  133-9     Citation Subset:  IM    
Department of Physiology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan.
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MeSH Terms
Anoxia / physiopathology
Blood Gas Analysis
Hypercapnia / physiopathology
Mice, Inbred C57BL
Prone Position / physiology*
Pulmonary Ventilation*
Supine Position / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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