| Effect of body fat on exercise hemodynamics in sedentary older men. | |
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MedLine Citation:
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PMID: 7880874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Morbid obesity is often associated with cardiac dilatation and left ventricular dysfunction. The present study investigated whether a similar relationship exists between mild and moderate obesity and left ventricular reserve function in 28 middle aged and older men (58.6 +/- 6.1 years, mean +/- SD). Subjects had a body mass index of 26.4 +/- 2.9 kg/m2, a percent body fat determined by hydrodensitometry ranging from 9.5% to 33.8%, and were carefully screened to exclude cardiovascular disease. Left ventricular function was assessed by gated blood pool scans at rest and during exhaustive upright cycle exercise. There were no significant relationships between resting or exercise cardiac volumes or ejection fraction with percent body fat; however, peak work rate/kg correlated inversely with percent body fat (r = -0.68, p < 0.0001). Heart rate reserve, defined as heart rate at peak work rate minus resting heart rate, declined significantly with increasing percent body fat (r = -0.47, p = 0.01). End diastolic volume index reserve also tended to decline with increasing percent body fat, but stroke volume index and cardiac index reserve were maintained because the decrease in end systolic volume index from rest to maximal exercise was greatest in those subjects with highest percent body fat (r = -0.41, p = 0.03). Therefore, rest and exercise left ventricular function are not related to percent body fat in healthy older men. However, older more obese men have a smaller increase in heart rate and end diastolic volume and a greater decrease in end systolic volume from rest to peak effort as a mechanism to augment exercise cardiac output. |
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Authors:
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F O'Connor; J L Fleg; G Gerstenblith; L C Becker; A P Goldberg; J M Hagberg; L Lakatta; E G Lakatta; S P Schulman |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Aging (Milan, Italy) Volume: 6 ISSN: 0394-9532 ISO Abbreviation: Aging (Milano) Publication Date: 1994 Aug |
Date Detail:
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Created Date: 1995-04-11 Completed Date: 1995-04-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9102503 Medline TA: Aging (Milano) Country: ITALY |
Other Details:
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Languages: eng Pagination: 257-65 Citation Subset: IM |
Affiliation:
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Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Body Mass Index Cardiac Volume Exercise* Gated Blood-Pool Imaging Hemodynamics* Humans Male Middle Aged Obesity / physiopathology* Ventricular Function, Left* |
| Grant Support | |
ID/Acronym/Agency:
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P01-AG-0-4402-10/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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