Document Detail

Effect of blood transfusion on lipid peroxidation in preterm infants.
MedLine Citation:
PMID:  11815548     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To see whether there was a link between blood transfusion and lipid peroxidation as measured by urinary malondialdehyde (MDA) concentration in preterm infants. METHODS: Urine samples were collected before and after blood transfusions in preterm infants. Twenty blood transfusion episodes were studied in 12 infants (some infants were studied on more than one occasion). Twenty two infants who had not received a transfusion were used as controls. All infants were preterm and less than 1500 g birth weight. Urinary MDA was measured using a thiobarbituric acid assay and expressed as nmol/mg creatinine. RESULTS: The median (interquartile range) urinary MDA concentration before transfusion was 9.1 (6.4-12.6) nmol/mg, and was not significantly different from that in the 22 non-transfused infants (11.3 (7.3-15.6) nmol/mg). There was a significant increase 24 hours after transfusion to 14.6 (7.3-23.7) nmol/mg, but it decreased to 10.1 (6.6-15.4) nmol/mg when measured a median (range) of 6 (3-9) days later. CONCLUSIONS: Blood transfusions were associated with evidence of increased lipid peroxidation. If lipid peroxidation contributes to the pathogenesis of retinopathy of prematurity and chronic lung disease, these results suggest an explanatory mechanism.
S P Wardle; J Drury; R Garr; A M Weindling
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of disease in childhood. Fetal and neonatal edition     Volume:  86     ISSN:  1359-2998     ISO Abbreviation:  Arch. Dis. Child. Fetal Neonatal Ed.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-29     Completed Date:  2002-02-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9501297     Medline TA:  Arch Dis Child Fetal Neonatal Ed     Country:  England    
Other Details:
Languages:  eng     Pagination:  F46-8     Citation Subset:  AIM; IM    
Neonatal Unit, Liverpool Women's Hospital, Liverpool, UK.
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MeSH Terms
Biological Markers / urine
Blood Transfusion*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / physiopathology,  therapy*,  urine
Infant, Very Low Birth Weight
Lipid Peroxidation*
Malondialdehyde / urine
Reg. No./Substance:
0/Biological Markers; 542-78-9/Malondialdehyde

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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