Document Detail

Effect of blood pH on distal nephron hydrogen ion secretion.
MedLine Citation:
PMID:  6772867     Owner:  NLM     Status:  MEDLINE    
The purpose o this study was to determine the effect of changes in blood hydrogen ion concentrations on urine acidification. The urine minus the blood PCO2 gradient in alkaline urine was used to monitor distal nephron hydrogen ion secretion. To obtain alkaline urine during acidemia, we induced proximal renal tubular acidosis by lysine. The urine minus the blood PCO2 gradient was evaluated relative to the urine bicarbonate concentration over a range of blood pH values. For any given urine bicarbonate concentration, the urine minus the blood PCO2 gradient was directly related to the blood hydrogen ion concentration. Conclusions. Acidemia stimulates and alkalemia inhibits distal nephron hydrogen ion secretion. Because the slope relating the urine minus the blood PCO2 gradient to the urine bicarbonate concentration was much steeper in urine from acidemic dogs, this change in relationship cannot be explained by a simple chemical equilibrium of the bicarbonate buffer system.
A Gougoux; P Vinay; G Lemieux; R M Richardson; S Tam; M B Goldstein; B J Stinebaugh; M L Halperin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  17     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-10-24     Completed Date:  1980-10-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  615-21     Citation Subset:  IM    
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MeSH Terms
Acid-Base Equilibrium / drug effects
Acidosis / metabolism
Alkalosis / metabolism
Bicarbonates / urine
Hydrogen-Ion Concentration*
Lysine / pharmacology
Nephrons / secretion*
Reg. No./Substance:
0/Bicarbonates; 56-87-1/Lysine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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