Document Detail


Effect of blood pH on distal nephron hydrogen ion secretion.
MedLine Citation:
PMID:  6772867     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose o this study was to determine the effect of changes in blood hydrogen ion concentrations on urine acidification. The urine minus the blood PCO2 gradient in alkaline urine was used to monitor distal nephron hydrogen ion secretion. To obtain alkaline urine during acidemia, we induced proximal renal tubular acidosis by lysine. The urine minus the blood PCO2 gradient was evaluated relative to the urine bicarbonate concentration over a range of blood pH values. For any given urine bicarbonate concentration, the urine minus the blood PCO2 gradient was directly related to the blood hydrogen ion concentration. Conclusions. Acidemia stimulates and alkalemia inhibits distal nephron hydrogen ion secretion. Because the slope relating the urine minus the blood PCO2 gradient to the urine bicarbonate concentration was much steeper in urine from acidemic dogs, this change in relationship cannot be explained by a simple chemical equilibrium of the bicarbonate buffer system.
Authors:
A Gougoux; P Vinay; G Lemieux; R M Richardson; S Tam; M B Goldstein; B J Stinebaugh; M L Halperin
Related Documents :
22401977 - Influence of bitches sex pheromones on the heart rate and other chosen parameters of bl...
22675537 - In vivo detection of amyloid-β deposits using heavy chain antibody fragments in a trans...
22183517 - Generation, detection and prevention of gaseous microemboli during cardiopulmonary bypa...
21596587 - Arthroscopic suture bridge transosseus equivalent fixation of rotator cuff tendon prese...
6591987 - Leucocyte removal prior to study of erythrocyte deformability.
2783927 - The effect of acetazolamide on regional cerebral blood flow in patients with alzheimer'...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Kidney international     Volume:  17     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1980 May 
Date Detail:
Created Date:  1980-10-24     Completed Date:  1980-10-24     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  615-21     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Acid-Base Equilibrium / drug effects
Acidosis / metabolism
Alkalosis / metabolism
Animals
Bicarbonates / urine
Dogs
Female
Hydrogen-Ion Concentration*
Lysine / pharmacology
Nephrons / secretion*
Chemical
Reg. No./Substance:
0/Bicarbonates; 56-87-1/Lysine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of hyperbaric oxygenation on pulmonary function, acid-base state and the blood gas compositio...
Next Document:  Hematopoietic stimulation for enhanced bone marrow regeneration after chemotherapy (author's transl)