| Effect of blood decrease on micafungin disposition in rats. | |
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MedLine Citation:
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PMID: 21350921 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Micafungin (MCFG) is a novel echinocandin-class antifungal agent that extensively undergoes metabolic removal in the liver. In the present study, the influence of decreased blood volume on pharmacokinetic disposition of MCFG was examined using a rat model prepared by phlebotomy. In phlebotomized rats, hematocrit level and plasma albumin concentration were decreased by 50 and 15%, respectively. Regarding the pharmacokinetic parameters of MCFG, there were no significant differences in the total body clearance (CL(tot)) and elimination rate constant (k (e)) between control and phlebotomized rat groups. A slight increase was observed in the apparent volume of distribution at steady-state (Vd(ss)), but the degree of change was minimal. These findings demonstrate that the elimination capacity for MCFG is only slightly affected by severe anemia and moderate hypoalbuminemia, and provide experimental evidence for the preceding clinical studies suggesting that neither hematocrit level nor serum albumin concentration is a contributory factor for the metabolic clearance of MCFG. |
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Authors:
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Hiroki Konishi; Keizo Fukushima; Masatomo Sudo; Masaki Sumi; Tokuzo Minouchi; Ikumi Iga; Nobuhito Shibata; Akira Yamaji |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-25 |
Journal Detail:
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Title: European journal of drug metabolism and pharmacokinetics Volume: - ISSN: 0378-7966 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7608491 Medline TA: Eur J Drug Metab Pharmacokinet Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Laboratory of Clinical Pharmacy and Therapeutics, Faculty of Pharmacy, Osaka Ohtani University, 3-11-1 Nishikiori-kita, Tondabayashi, 548-8540, Japan, konishih@osaka-ohtani.ac.jp. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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