Document Detail

Effect of biventricular pacing on diastolic dyssynchrony.
MedLine Citation:
PMID:  21029873     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study sought to examine the changes in diastolic dyssynchrony with cardiac resynchronization therapy (CRT).
BACKGROUND: Little is known about the effect of CRT on diastolic dyssynchrony.
METHODS: Consecutive heart failure patients (n = 266, age 65.7 ± 10.0 years) underwent color-coded tissue Doppler imaging at baseline, 48 h, and 6 months after CRT. Systolic and diastolic dyssynchrony were defined as maximal time delay in peak systolic and early diastolic velocities, respectively, in 4 basal LV segments. CRT responders were defined as those with ≥15% decrease in LV end-systolic volume at 6 months.
RESULTS: Baseline LVEF was 25.2 ± 8.1%; 63.5% patients were CRT responders. Baseline incidence of systolic and diastolic dyssynchrony, and a combination of both was 46.2%, 51.9%, and 28.6%, respectively. Compared to nonresponders, responders had longer baseline systolic (79.2 ± 43.4 ms vs. 45.4 ± 30.4 ms; p < 0.001) and diastolic (78.5 ± 52.0 ms vs. 50.1 ± 38.2 ms; p < 0.001) delays. In follow-up, systolic delays (45.4 ± 31.6 ms at 48 h; 38.9 ± 26.2 ms at 6 months; p < 0.001) and diastolic delays (49.4 ± 36.3 ms at 48 h; 37.7 ± 26.0 ms at 6 months; p < 0.001) improved only in responders.
CONCLUSIONS: At baseline: 1) diastolic dyssynchrony was more common than systolic dyssynchrony in HF patients; 2) nonresponders had less baseline diastolic dyssynchrony compared to responders. After CRT: 1) diastolic dyssynchrony improved only in responders. Further insight into the pathophysiology of diastolic dyssynchrony and its changes with CRT may provide incremental information on patient-specific treatments.
Miriam Shanks; Matteo Bertini; Victoria Delgado; Arnold C T Ng; Gaetano Nucifora; Rutger J van Bommel; C Jan Willem Borleffs; Eduard R Holman; Nico R L van de Veire; Martin J Schalij; Jeroen J Bax
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  56     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-29     Completed Date:  2010-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1567-75     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
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MeSH Terms
Cardiac Pacing, Artificial* / methods
Diastole / physiology
Follow-Up Studies
Heart Failure, Diastolic / physiopathology*,  therapy*
Middle Aged
Treatment Outcome
Ventricular Dysfunction, Left / physiopathology*,  therapy*

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