Document Detail

Effect of bis (tributyl tin) oxide on permeability of the blood-brain barrier: a transient increase.
MedLine Citation:
PMID:  7849849     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To study the effect of bis (tributyl tin) oxide (TBTO) on permeability of the blood-brain barrier. METHODS: Electron microscopy and an x ray microanalyser with lanthanum chloride as a tracer were used, and blood tin concentrations were determined with an atomic absorption spectrophotometer. Adult male wistar rats received 0.05 ml/kg body weight of TBTO orally. RESULTS: A transient increase in paracellular permeability at the blood-brain barrier was found 2 h after the dose of TBTO. Electron dense lanthanum deposits penetrated tight junctions of the endothelia and permeated the subendothelial space. The x ray microprobe data showed an accumulation of TBTO at the tight junctions at 2 h. Leakage of tracer did not occur at 4 h, but oedematous changes in the surrounding glial cells were prominent between 4 and 8 h and had almost returned to normal by 24 h. By atomic absorption analysis, it was seen that blood tin concentrations rapidly increased at 1 h and rose to a maximum peak at 8 h, then gradually decreased to reach zero at 24 h. CONCLUSIONS: Accumulated TBTO at tight junctions could have caused the temporary replacement of calcium ion by tin, which induces a transient increase in paracellular permeability throughout the blood-brain barrier.
K Hara; M Yoshizuka; Y Doi; S Fujimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  51     ISSN:  1351-0711     ISO Abbreviation:  Occup Environ Med     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-03-14     Completed Date:  1995-03-14     Revised Date:  2010-03-24    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  735-8     Citation Subset:  IM    
Department of Anatomy, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan.
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MeSH Terms
Blood-Brain Barrier / drug effects*
Immunosuppressive Agents / administration & dosage,  blood,  pharmacokinetics*
Intercellular Junctions / drug effects*
Microscopy, Electron
Rats, Wistar
Spectrophotometry, Atomic
Time Factors
Trialkyltin Compounds / administration & dosage,  blood,  pharmacokinetics*
Reg. No./Substance:
0/Immunosuppressive Agents; 0/Trialkyltin Compounds; 56-35-9/bis(tri-n-butyltin)oxide

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