Document Detail

Effect of the bioflavonoid silymarin on the in vitro activity and expression of superoxide dismutase (SOD) enzyme.
MedLine Citation:
PMID:  1763650     Owner:  NLM     Status:  MEDLINE    
Superoxide dismutase activity and expression of the erythrocytes and lymphocytes of patients suffering from chronic alcoholic liver disease and those of healthy controls were investigated after in vitro incubation with silymarin. It was concluded that silymarin treatment in a concentration achievable by in vivo treatment (10 micrograms/ml) significantly increased the SOD activity of both the erythrocytes and lymphocytes of patients with liver disease, whereas the SOD expression of the lymphocytes enhanced to a considerable extent. These results indirectly indicate that the scavenger silymarin is able to increase the antioxidant protection of the cells by ameliorating the deleterious effects of free radical reactions.
G Müzes; G Deák; I Láng; K Nékám; P Gergely; J Fehér
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Hungarica     Volume:  78     ISSN:  0231-424X     ISO Abbreviation:  Acta Physiol Hung     Publication Date:  1991  
Date Detail:
Created Date:  1992-02-07     Completed Date:  1992-02-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8309201     Medline TA:  Acta Physiol Hung     Country:  HUNGARY    
Other Details:
Languages:  eng     Pagination:  3-9     Citation Subset:  IM    
2nd Department of Medicine, Semmelweis University, Budapest, Hungary.
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MeSH Terms
Antioxidants / pharmacology*
Cell Membrane / enzymology
Erythrocytes / enzymology
Flow Cytometry
Liver Diseases, Alcoholic / blood,  enzymology
Lymphocytes / enzymology
Middle Aged
Silymarin / pharmacology*
Superoxide Dismutase / biosynthesis,  metabolism*
Reg. No./Substance:
0/Antioxidants; 0/Silymarin; EC Dismutase

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