| Effect of biliary obstruction on muscle relaxation with vecuronium. | |
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MedLine Citation:
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PMID: 2897913 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vecuronium bromide was used as a muscle relaxant in 30 patients undergoing biliary surgery. Ten patients had biliary obstruction, 10 patients without biliary obstruction were elderly (78 +/- 1.2 yrs; mean +/- SEM) and 10 patients without biliary obstruction were young or middle-aged (35 +/- 3.0 yrs). The muscle response to ulnar nerve stimulation was measured electromyographically. The results indicate that the neuromuscular blocking effect of vecuronium is significantly prolonged in patients with biliary obstruction. The mean total dose of vecuronium was lower in the patients with biliary obstruction (1.2 +/- 0.1 micrograms kg-1 min-1) than in the elderly patients (1.7 +/- 0.2 micrograms kg-1 min-1) and young patients (2.0 +/- 0.2 micrograms kg-1 min-1; P less than 0.05). There were no statistically significant differences in the distribution half-lives or in the distribution volumes of vecuronium between the groups. |
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Authors:
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R Orko; A Alila; P H Rosenberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of anaesthesiology Volume: 5 ISSN: 0265-0215 ISO Abbreviation: Eur J Anaesthesiol Publication Date: 1988 Jan |
Date Detail:
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Created Date: 1988-07-27 Completed Date: 1988-07-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8411711 Medline TA: Eur J Anaesthesiol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 9-14 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia, Surgical Hospital, Helsinki, Finland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Blood Pressure / drug effects Cholestasis / physiopathology* Female Heart Rate / drug effects Humans Male Middle Aged Neuromuscular Junction / drug effects* Vecuronium Bromide / blood, pharmacology* |
| Chemical | |
Reg. No./Substance:
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50700-72-6/Vecuronium Bromide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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