| Effect of bile salts and fatty acids on the colonic absorption of oxalate. | |
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MedLine Citation:
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PMID: 1269869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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These studies were designed to evaluate the effect of bile salts and fatty acids on colonic oxalate absorption. Five millimolar deoxycholate significantly increased oxalate absorption from 34.2 +/- 9.4 nmoles per min per g dry weight to 330.4 +/- 47.3 (P less than 0.001) and changed water absorption to water secretion. Deoxycholate also increased the absorption of urea, decreased the electrical potential difference, and increased colonic clearance of oxalate, observations which are consistent with an increase in colonic mucosal permeability. In contrast, taurocholate did not increase oxalate absorption. Ricinoleic acid also significantly increased the absorption. These results suggest that bile salts and fatty acids increase colonic absorption of oxalate. Oleic acid had similar effects on oxalate absorption but was less effective than ricinoleic acid. Octanoic acid, a medium chain fatty acid, did not alter oxalate absorption of oxalate by a nonspecific alteration of mucosal permeability. These observations may further explain many of the clinical phenomena associated with enteric hyperoxaluria. |
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Authors:
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J W Dobbins; H J Binder |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Gastroenterology Volume: 70 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1976 Jun |
Date Detail:
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Created Date: 1976-08-02 Completed Date: 1976-08-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1096-1100 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile Acids and Salts / pharmacology* Colon / drug effects, metabolism* Deoxycholic Acid / pharmacology Electrophysiology Fatty Acids / pharmacology* Intestinal Absorption / drug effects* Male Octanoic Acids / pharmacology Oleic Acids / pharmacology Oxalates / metabolism* Rats Ricinoleic Acids / pharmacology Taurocholic Acid / pharmacology Water / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Fatty Acids; 0/Octanoic Acids; 0/Oleic Acids; 0/Oxalates; 0/Ricinoleic Acids; 7732-18-5/Water; 81-24-3/Taurocholic Acid; 83-44-3/Deoxycholic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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