| Effect of bevantolol and propranolol on serum lipids in patients with essential hypertension. | |
| | |
MedLine Citation:
|
PMID: 7881705 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In patients with essential hypertension, the beta-blockers bevantolol or propranolol were administered once or twice a day for twelve weeks to evaluate the effects on blood pressure, and lipid metabolism. Both systolic and diastolic blood pressure decreased significantly in response to both bevantolol and propranolol. The pulse-rate also decreased significantly in both groups. Total cholesterol did not change significantly in both groups. Triglycerides increased significantly in the bevantolol group. HDL cholesterol decreased significantly in the propranolol group. The LDL cholesterol/HDL cholesterol ratio increased significantly in the propranolol group, while no significant increase was observed in the bevantolol group. The apolipoprotein B/A ratio was elevated in the propranolol group. No serious side-effects were noted during the study in both groups. These results indicate that bevantolol is an effective antihypertensive drug with fewer unfavorable effects on lipid metabolism than propranolol. |
| | |
Authors:
|
J Sasaki; G Kajiyama; R Kusukawa; H Mori; S Koga; R Takagi; N Tanaka; N Ogawa; K Arakawa |
Related Documents
:
|
1511475 - Effects on serum lipids of adding fruits and vegetables to prudent diet in the indian e... 1201145 - Long-term effects of colestipol (u-26,597 a) on plasma lipids in familial type ii hyper... 21447765 - Low-residue diet in diverticular disease: putting an end to a myth. 20797475 - Flaxseed lignan lowers blood cholesterol and decreases liver disease risk factors in mo... 9577345 - Leucocyte endothelial cell adhesion in indomethacin induced intestinal inflammation is ... 628315 - Nutritional and metabolic studies of distillable fractions from fresh and thermally oxi... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
|
Title: International journal of clinical pharmacology and therapeutics Volume: 32 ISSN: 0946-1965 ISO Abbreviation: Int J Clin Pharmacol Ther Publication Date: 1994 Dec |
Date Detail:
|
Created Date: 1995-04-10 Completed Date: 1995-04-10 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9423309 Medline TA: Int J Clin Pharmacol Ther Country: GERMANY |
Other Details:
|
Languages: eng Pagination: 660-4 Citation Subset: IM |
Affiliation:
|
2nd Department of Internal Medicine, Fukuoka University, School of Medicine, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic beta-Antagonists
/
pharmacology*,
therapeutic use Adult Aged Apolipoproteins / blood, drug effects Blood Pressure / drug effects Fatty Acids, Nonesterified / blood Female Humans Hypertension / blood, drug therapy*, physiopathology Lipids / blood* Lipoproteins / blood, drug effects Male Middle Aged Propanolamines / pharmacology*, therapeutic use Propranolol / pharmacology* Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Antagonists; 0/Apolipoproteins; 0/Fatty Acids, Nonesterified; 0/Lipids; 0/Lipoproteins; 0/Propanolamines; 0/Triglycerides; 525-66-6/Propranolol; 59170-23-9/bevantolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Crossover comparison of the effects of enalapril and captopril on potassium homeostasis in patients ...
Next Document: Analysis of pharmacokinetic-dynamic interrelations with special reference to applications in cardiov...