Document Detail

Effect of bevantolol and propranolol on serum lipids in patients with essential hypertension.
MedLine Citation:
PMID:  7881705     Owner:  NLM     Status:  MEDLINE    
In patients with essential hypertension, the beta-blockers bevantolol or propranolol were administered once or twice a day for twelve weeks to evaluate the effects on blood pressure, and lipid metabolism. Both systolic and diastolic blood pressure decreased significantly in response to both bevantolol and propranolol. The pulse-rate also decreased significantly in both groups. Total cholesterol did not change significantly in both groups. Triglycerides increased significantly in the bevantolol group. HDL cholesterol decreased significantly in the propranolol group. The LDL cholesterol/HDL cholesterol ratio increased significantly in the propranolol group, while no significant increase was observed in the bevantolol group. The apolipoprotein B/A ratio was elevated in the propranolol group. No serious side-effects were noted during the study in both groups. These results indicate that bevantolol is an effective antihypertensive drug with fewer unfavorable effects on lipid metabolism than propranolol.
J Sasaki; G Kajiyama; R Kusukawa; H Mori; S Koga; R Takagi; N Tanaka; N Ogawa; K Arakawa
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology and therapeutics     Volume:  32     ISSN:  0946-1965     ISO Abbreviation:  Int J Clin Pharmacol Ther     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-04-10     Completed Date:  1995-04-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9423309     Medline TA:  Int J Clin Pharmacol Ther     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  660-4     Citation Subset:  IM    
2nd Department of Internal Medicine, Fukuoka University, School of Medicine, Japan.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology*,  therapeutic use
Apolipoproteins / blood,  drug effects
Blood Pressure / drug effects
Fatty Acids, Nonesterified / blood
Hypertension / blood,  drug therapy*,  physiopathology
Lipids / blood*
Lipoproteins / blood,  drug effects
Middle Aged
Propanolamines / pharmacology*,  therapeutic use
Propranolol / pharmacology*
Triglycerides / blood
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Apolipoproteins; 0/Fatty Acids, Nonesterified; 0/Lipids; 0/Lipoproteins; 0/Propanolamines; 0/Triglycerides; 525-66-6/Propranolol; 59170-23-9/bevantolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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