Document Detail


Effect of betamethasone and exercise on equine carpal joints with osteochondral fragments.
MedLine Citation:
PMID:  7839595     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Osteochondral fragments were created arthroscopically on the distal aspect of both radial carpal bones in 12 horses. On day 14 after surgery, one middle carpal joint of each horse was injected with 2.5 mL Betavet Soluspan (3.9 mg betamethasone sodium phosphate and 12 mg betamethasone acetate per milliliter) and the contralateral joint was injected with 2.5 mL saline as a control. Intra-articular treatments were repeated on day 35. On day 17, six horses began exercising 5 days per week on a high-speed treadmill. The other six horses were kept in box stalls throughout the study as nonexercised controls. On day 56, all horses were examined clinically and radiographically and then were euthanatized. Samples were obtained for histological, histochemical, and biochemical evaluation. Mild lameness was observed in five of the six exercised horses at day 56; four horses were lame in the control limb and one horse was lame in the treated limb. Of the five nonexercised horses evaluated for lameness, two were lame in the control limb, two were lame in the treated limb, and one was lame in both the control and the treated limb. No differences were noted on radiographs or palpation of steroid treated limbs versus control limbs. Firm reattachment of the osteochondral fragment to the radial carpal bone occurred in all but three joints. Gross cartilage damage was not different between steroid-treated joints and joints injected with saline. Histologically, there were no significant detrimental effects of beta-methasone with or without exercise, but there was a tendency for more pathological change in treated joints. No significant difference in the water content or uronic acid concentration was detected between treated and control joints. Intra-articular betamethasone administration in this carpal chip model was not associated with any significant detrimental effects in either rested or exercised horses.
Authors:
J W Foland; C W McIlwraith; G W Trotter; B E Powers; C H Lamar
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Veterinary surgery : VS     Volume:  23     ISSN:  0161-3499     ISO Abbreviation:  Vet Surg     Publication Date:    1994 Sep-Oct
Date Detail:
Created Date:  1995-03-02     Completed Date:  1995-03-02     Revised Date:  2011-04-25    
Medline Journal Info:
Nlm Unique ID:  8113214     Medline TA:  Vet Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  369-76     Citation Subset:  IM    
Affiliation:
Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins 80523.
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MeSH Terms
Descriptor/Qualifier:
Animals
Betamethasone / administration & dosage,  therapeutic use*
Carpus, Animal*
Cartilage, Articular / pathology
Horse Diseases / therapy*
Horses
Injections, Intra-Articular / veterinary
Joint Diseases / therapy,  veterinary*
Lameness, Animal / therapy
Physical Conditioning, Animal*
Synovial Membrane / pathology
Chemical
Reg. No./Substance:
378-44-9/Betamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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