Document Detail

Effect of beta2-adrenergic receptor functioning and increased norepinephrine on the hypercoagulable state with mental stress.
MedLine Citation:
PMID:  12094190     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Procoagulant stress responses may contribute to atherosclerosis development and acute coronary thrombosis. In the present study, we examined the role of beta2-adrenergic receptor function and plasma catecholamines in the stress-induced increase in the 2 hypercoagulability markers thrombin-antithrombin III (TAT) complex and fibrin D-dimer (DD). METHODS: Lymphocyte beta2-adrenoreceptor sensitivity and density were assessed at rest, and plasma levels of TAT, DD, epinephrine, and norepinephrine were measured at rest and in response to a standardized mental stress task in 19 normotensive and mildly hypertensive nonmedicated subjects (mean age 38 years, age range 29 to 48 years). RESULTS: The stressor elicited a significant increase in TAT (P =.024), DD (P =.026), and norepinephrine (P =.005). Resting beta2-adrenoreceptor sensitivity (isoproterenol-stimulated cyclic adenosine monophosphate production) plus the norepinephrine change scores (stress minus rest) accounted for 59% of the variance in the absolute TAT increase in response to stress (P =.001). Hypertension status and demographic variables such as sex did not influence the results. CONCLUSIONS: Acute mental stress may trigger a hypercoagulable state evidenced by increased thrombin activity and increased fibrin turnover. Beta2-adrenergic receptor sensitivity and plasma catecholamine activity may mediate the procoagulant response to acute stressors. These mechanisms may help explain the adverse impact of mental stress on the cardiovascular system.
Roland von Känel; Paul J Mills; Michael G Ziegler; Joel E Dimsdale
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American heart journal     Volume:  144     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-02     Completed Date:  2002-07-18     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  68-72     Citation Subset:  AIM; IM    
Department of Psychiatry, University of California, San Diego, Calif 92093-0804, USA.
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MeSH Terms
Epinephrine / blood*
Fibrin Fibrinogen Degradation Products / metabolism*
Lymphocytes / metabolism
Middle Aged
Norepinephrine / blood*
Receptors, Adrenergic, beta-2 / physiology*
Regression Analysis
Stress, Psychological / blood*
Grant Support
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/Receptors, Adrenergic, beta-2; 0/fibrin fragment D; 51-41-2/Norepinephrine; 51-43-4/Epinephrine

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