| Effect of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor atorvastatin on contractility of the isolated rat heart under normal conditions and during oxidative stress. | |
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MedLine Citation:
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PMID: 18214286 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Long-term administration of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor atorvastatin to rats was accompanied by an increase in the relative weight of the heart and decrease in the rate of pressure development in the isovolumic heart. During oxidative stress induced by addition of 100 microM H2O2 to the perfusate, the decrease in contractile function was more pronounced that in the control. Our results indicate that administration of atorvastatin is accompanied by a decrease in myocardial contractility, which becomes more pronounced under conditions of oxidative stress. |
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Authors:
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V L Lakomkin; V I Kapel'ko; V Z Lankin; G G Konovalova; A I Kaminnyi |
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Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: Bulletin of experimental biology and medicine Volume: 143 ISSN: 0007-4888 ISO Abbreviation: Bull. Exp. Biol. Med. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2008-01-24 Completed Date: 2008-03-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372557 Medline TA: Bull Exp Biol Med Country: United States |
Other Details:
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Languages: eng Pagination: 408-10 Citation Subset: IM |
Affiliation:
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Russian Cardiology Research-and-Production Complex, Federal Agency for Health Protection and Social Development, Moscow. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Heart / drug effects, physiology Heptanoic Acids / pharmacology* Hydrogen Peroxide / pharmacology Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology* Myocardial Contraction / drug effects* Oxidative Stress / physiology* Pyrroles / pharmacology* Rats Rats, Wistar |
| Chemical | |
Reg. No./Substance:
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0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 110862-48-1/atorvastatin; 7722-84-1/Hydrogen Peroxide |
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