Document Detail

Effect of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor atorvastatin on contractility of the isolated rat heart under normal conditions and during oxidative stress.
MedLine Citation:
PMID:  18214286     Owner:  NLM     Status:  MEDLINE    
Long-term administration of beta-hydroxy-beta-methylglutaryl coenzyme A reductase inhibitor atorvastatin to rats was accompanied by an increase in the relative weight of the heart and decrease in the rate of pressure development in the isovolumic heart. During oxidative stress induced by addition of 100 microM H2O2 to the perfusate, the decrease in contractile function was more pronounced that in the control. Our results indicate that administration of atorvastatin is accompanied by a decrease in myocardial contractility, which becomes more pronounced under conditions of oxidative stress.
V L Lakomkin; V I Kapel'ko; V Z Lankin; G G Konovalova; A I Kaminnyi
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  143     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2008-01-24     Completed Date:  2008-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  408-10     Citation Subset:  IM    
Russian Cardiology Research-and-Production Complex, Federal Agency for Health Protection and Social Development, Moscow.
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MeSH Terms
Heart / drug effects,  physiology
Heptanoic Acids / pharmacology*
Hydrogen Peroxide / pharmacology
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology*
Myocardial Contraction / drug effects*
Oxidative Stress / physiology*
Pyrroles / pharmacology*
Rats, Wistar
Reg. No./Substance:
0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 110862-48-1/atorvastatin; 7722-84-1/Hydrogen Peroxide

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