Document Detail

Effect of beta-carotene on immunological indexes in healthy male smokers.
MedLine Citation:
PMID:  8438775     Owner:  NLM     Status:  MEDLINE    
To evaluate the immunomodulatory effects of beta-carotene we performed a randomized, double-blind trial in healthy male cigarette smokers. Lymphocyte subsets in peripheral blood were assessed by using double labeling with monoclonal antibodies before and after 14 wk beta-carotene (20 mg/d; n = 21) or placebo (n = 24) supplements. In addition we measured the ex vivo phytohemagglutinin and concanavalin A induced lymphocyte proliferation in a separate group (23 placebo, 24 beta-carotene). The beta-carotene and placebo groups were comparable on all initial characteristics. During the intervention plasma concentrations of beta-carotene increased 13-fold in the treatment group whereas retinol concentrations remained constant. Beta-carotene had no effect on lymphocyte subpopulations in peripheral blood. After treatment the beta-carotene group showed 12% higher PHA-induced lymphocyte proliferations than the placebo group (P = 0.02). For ConA induced proliferations no significant difference was observed. These results suggest that supplementary beta-carotene can moderately enhance certain aspects of immune response in healthy male cigarette smokers.
G van Poppel; S Spanhaak; T Ockhuizen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  57     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-03-25     Completed Date:  1993-03-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  402-7     Citation Subset:  AIM; IM    
The Netherlands Organization for Applied Scientific Research, (TNO) Toxicology and Nutrition Institute, Zeist.
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MeSH Terms
Antibodies, Monoclonal
Carotenoids / blood,  pharmacology*,  therapeutic use
Concanavalin A / pharmacology
Double-Blind Method
Leukocyte Count
Lymphocyte Activation / drug effects
Lymphocyte Subsets / drug effects
Middle Aged
Phytohemagglutinins / pharmacology
Smoking / blood*
Vitamin A / blood
beta Carotene
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Phytohemagglutinins; 11028-71-0/Concanavalin A; 11103-57-4/Vitamin A; 36-88-4/Carotenoids; 7235-40-7/beta Carotene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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