Document Detail

Effect of beta blockers on central aortic pressure in African-Americans.
MedLine Citation:
PMID:  21414564     Owner:  NLM     Status:  In-Data-Review    
The objective of this study was to evaluate the vascular effects of heart rate (HR) reduction with BB therapy in African Americans (AA). Beta-blockers (BB) offer less cardiovascular protection than other hypertensive drugs. Studies of Caucasian subjects suggest this may be due to an adverse effect of HR lowering on arterial wave reflection. We studied 506 subjects (age 63 ± 14 years, 52% were treated with BB). Central systolic (C-SBP) and pulse pressure (C-PP), augmented pressure (AP), and augmentation index (AI) were obtained via applanation tonometry (Sphygmocor). On univariate analysis, HR correlated inversely with BB use, C-SBP, AP, and AI (all P < .001), but not P-SBP. Multivariate analysis showed P-SBP and HR to be major determinants of C-SBP (R(2) = 0.95). Generalized linear model analysis showed higher C-SBP (P < .05) and C-PP (P = .04), but similar P-SBP (P = .24) in the BB group. After HR adjustment, differences in C-SBP, C-PP, AI, and AP were attenuated, suggesting HR to be a determinant of C-SBP. BB use is associated with higher C-SBP and lower PPA in hypertensive AA despite similar P-SBP. C-SBP is HR-dependent. HR reduction with BB accounts for less effective central blood pressure control in AA, similar to that reported in Caucasians.
Haroon Kamran; Louis Salciccioli; Carl Bastien; Patricia Castro; Abhishek Sharma; Jason M Lazar
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American Society of Hypertension : JASH     Volume:  5     ISSN:  1933-1711     ISO Abbreviation:  J Am Soc Hypertens     Publication Date:    2011 Mar-Apr
Date Detail:
Created Date:  2011-03-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101312518     Medline TA:  J Am Soc Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  94-101     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
Division of Cardiovascular Medicine, State University of New York Downstate Medical Center, Brooklyn, New York.
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