| Effect of beta blockers (carvedilol or metoprolol XL) in patients with transposition of great arteries and dysfunction of the systemic right ventricle. | |
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MedLine Citation:
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PMID: 17317376 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study evaluated the effects of beta blockers (carvedilol and metoprolol XL) on New York Heart Association functional class and systemic right ventricular (RV) function in patients with complete transposition of the great arteries who had systemic RV dysfunction late after atrial inflow correction. A significant improvement in New York Heart Association functional class was found after 4 months of therapy with beta blockers. Functional recovery was significant mostly in those patients with pacemakers who received higher maintenance doses of carvedilol. RV end-diastolic area was significantly greater in untreated patients at the end of the follow-up period, whereas it was unchanged in treated patients. In conclusion, beta blockers prevent RV remodeling, with a concomitant improvement in exercise tolerance in patients with complete transposition of the great arteries and systemic RV dysfunction. |
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Authors:
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Abdul Rahman K Doughan; Michael E McConnell; Wendy M Book |
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Publication Detail:
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Type: Journal Article Date: 2007-01-08 |
Journal Detail:
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Title: The American journal of cardiology Volume: 99 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-02-23 Completed Date: 2007-04-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 704-6 Citation Subset: AIM; IM |
Affiliation:
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Adult Congenital Cardiac Program, Emory University School of Medicine, Atlanta, Georgia, USA. adougha@emory.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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therapeutic use* Adult Carbazoles / therapeutic use* Female Follow-Up Studies Humans Male Metoprolol / analogs & derivatives*, therapeutic use Propanolamines / therapeutic use* Retrospective Studies Stroke Volume / physiology Transposition of Great Vessels / complications*, physiopathology, ultrasonography Treatment Outcome Ventricular Dysfunction, Right / complications*, drug therapy*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 0/metoprolol succinate; 37350-58-6/Metoprolol; 72956-09-3/carvedilol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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