Document Detail

Effect of beta-blockers on beta3-adrenoceptor expression in chronic heart failure.
MedLine Citation:
PMID:  17440824     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To investigate the expression of beta(3)-adrenoceptors in rats with chronic heart failure, and to explore the effect of beta-blockers on beta(3)-adrenoceptor expression.
MATERIALS AND METHODS: Thirty-two male Wistar rats were divided into Sham (n = 10) and heart failure (n = 22) groups. The heart failure group was treated with normal saline (Heart Failure Control, n = 6), Metoprolol (n = 8) or Carvedilol (n = 8) for 3 months.
RESULTS: The left ventricular end systolic pressure (LVESP) and the absolute values of maximal rate of rise and fall of left ventricular pressure (+/-dP/dt max) in the heart failure group were lower than in the Sham group (P < 0.01), whereas the left ventricular end diastolic pressure (LVEDP) was higher (P < 0.01). The LVESP and dP/dtmax in the Carvedilol group were higher than the Metoprolol group whereas LVEDP was lower (P < 0.01). The left ventricular mass index (LVMI) in the Carvedilol group was less than the Metoprolol and Heart Failure Control groups (P < 0.01). The level of beta(3)-adrenoceptor expression in the study groups was significantly higher than the Sham group (P < 0.01). beta(3)-adrenoceptor expression in the Carvedilol group was lower than the Heart Failure Control and Metoprolol groups (P < 0.01).
CONCLUSION: beta(3)-adrenoceptor expression is increased in the failing ventricles in rats. Carvedilol is more effective than Metoprolol for improving the hemodynamics and in attenuating ventricular remodeling after heart failure. Carvedilol, rather than Metoprolol, diminishes beta(3)-adrenoceptor expression in the failing ventricles.
Qiang Zhao; Tong-Guo Wu; Zuo-Fen Jiang; Guo-Wei Chen; Yi Lin; Le-Xin Wang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  21     ISSN:  0920-3206     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-05-28     Completed Date:  2007-11-08     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-90     Citation Subset:  IM    
Department of Cardiology, The Red Cross Hospital of Guangzhou City, the Fourth Affiliated Hospital of Jinan University, Guangzhou 510220, People's Republic of China.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology*
Blood Pressure / drug effects
Carbazoles / pharmacology
Chronic Disease
Gene Expression
Heart Failure / metabolism*,  physiopathology
Heart Rate / drug effects
Metoprolol / pharmacology
Propanolamines / pharmacology
RNA, Messenger / biosynthesis
Rats, Wistar
Receptors, Adrenergic, beta-3 / biosynthesis*,  genetics
Vasodilator Agents / pharmacology
Ventricular Function, Left / drug effects
Ventricular Pressure / drug effects
Ventricular Remodeling / drug effects
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Carbazoles; 0/Propanolamines; 0/RNA, Messenger; 0/Receptors, Adrenergic, beta-3; 0/Vasodilator Agents; 0K47UL67F2/carvedilol; 37350-58-6/Metoprolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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