| Effect of beta blocker therapy on survival of patients with heart failure and preserved systolic function following hospitalization with acute decompensated heart failure. | |
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MedLine Citation:
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PMID: 22560389 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: The importance of heart failure with preserved ejection fraction is being increasingly recognized. However, there is a paucity of data about effective treatment for this condition. The present study investigated the impact of beta blocker therapy for 3months before admission on the two-year survival of patients with heart failure and preserved systolic function hospitalized due to decompensated heart failure. METHODS: We performed a retrospective cohort analysis of 345 consecutive patients with heart failure with preserved systolic function older than 18years hospitalized due to decompensated heart failure. Two groups of patients were compared: those who received beta blockers within 3months before admission (BB) and those who did not (NBB). The primary outcome was two year all cause mortality (maximal follow-up available in all subjects). To adjust for a potential misbalance between BB and NBB groups in baseline characteristics, a propensity score for beta blocker therapy was incorporated into the survival model. RESULTS: 154 patients (44.6%) received beta blockers prior to admission. Overall two year mortality rate in the BB group was 50% vs. 62.8% in the NBB group, log-rank test p=0.016. Beta blockers showed protective effect on two-year survival after adjustment for comorbidities and propensity score (hazard ratio [HR], 0.69; 95% CI 0.47-0.99). CONCLUSIONS: Therapy with beta blockers may have protective effect on survival of patients with heart failure with preserved systolic function. |
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Authors:
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Roman Nevzorov; Avi Porath; Yaakov Henkin; Sergio L Kobal; Alan Jotkowitz; Victor Novack |
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Publication Detail:
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Type: Journal Article Date: 2012-02-27 |
Journal Detail:
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Title: European journal of internal medicine Volume: 23 ISSN: 1879-0828 ISO Abbreviation: Eur. J. Intern. Med. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9003220 Medline TA: Eur J Intern Med Country: Netherlands |
Other Details:
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Languages: eng Pagination: 374-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2012. Published by Elsevier B.V. |
Affiliation:
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Department of Cardiology, Rabin Medical Center, Petah Tikva, Tel Aviv University's Sackler Medical School, Israel. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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