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Effect of beta blockade on natriuretic peptides and copeptin in elderly patients with heart failure and preserved or reduced ejection fraction: Results from the CIBIS-ELD trial.
MedLine Citation:
PMID:  22155435     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: We sought to investigate the effect of beta-blocker (BB) up-titration on serum levels of NT-proBNP and copeptin in patients with heart failure (HF) with reduced (HFREF) or preserved ejection fraction (HFPEF). METHODS: Serial measurements of NT-proBNP and copeptin were obtained after initiation of BB up-titration in 219 elderly patients with HFREF or HFPEF. RESULTS: After initial increasing trend of NT-proBNP at 6weeks in HFREF patients, there was a subsequent decrease at 12weeks of BB treatment up-titration (p=0.003), while no difference was found compared to baseline levels. In contrast to NT-proBNP, there was a continuous decreasing trend of copeptin in HFREF patients (at 12weeks: p=0.026). In HFPEF patients, NT-proBNP significantly decreased (p=0.043) compared to copeptin after 12weeks of BB up-titration. CONCLUSIONS: After 12weeks of BB optimization copeptin might reflect successful up-titration faster than NT-proBNP in HFREF, while the opposite was found in patients with HFPEF.
Authors:
Goran Loncar; Stephan von Haehling; Elvis Tahirovic; Simone Inkrot; Meinhard Mende; Nikola Sekularac; Mitja Lainscak; Svetlana Apostolovic; Biljana Putnikovic; Frank Edelmann; Rolf Wachter; Sinisa Dimkovic; Finn Waagstein; Götz Gelbrich; Hans-Dirk Düngen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-2
Journal Detail:
Title:  Clinical biochemistry     Volume:  -     ISSN:  1873-2933     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0133660     Medline TA:  Clin Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Affiliation:
Zvezdara University Medical Center, Department of cardiology, Dimitrija Tucovica 161, 11 000 Belgrade, Serbia.
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