| Effect of beta blockade on natriuretic peptides and copeptin in elderly patients with heart failure and preserved or reduced ejection fraction: Results from the CIBIS-ELD trial. | |
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MedLine Citation:
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PMID: 22155435 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: We sought to investigate the effect of beta-blocker (BB) up-titration on serum levels of NT-proBNP and copeptin in patients with heart failure (HF) with reduced (HFREF) or preserved ejection fraction (HFPEF). METHODS: Serial measurements of NT-proBNP and copeptin were obtained after initiation of BB up-titration in 219 elderly patients with HFREF or HFPEF. RESULTS: After initial increasing trend of NT-proBNP at 6weeks in HFREF patients, there was a subsequent decrease at 12weeks of BB treatment up-titration (p=0.003), while no difference was found compared to baseline levels. In contrast to NT-proBNP, there was a continuous decreasing trend of copeptin in HFREF patients (at 12weeks: p=0.026). In HFPEF patients, NT-proBNP significantly decreased (p=0.043) compared to copeptin after 12weeks of BB up-titration. CONCLUSIONS: After 12weeks of BB optimization copeptin might reflect successful up-titration faster than NT-proBNP in HFREF, while the opposite was found in patients with HFPEF. |
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Authors:
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Goran Loncar; Stephan von Haehling; Elvis Tahirovic; Simone Inkrot; Meinhard Mende; Nikola Sekularac; Mitja Lainscak; Svetlana Apostolovic; Biljana Putnikovic; Frank Edelmann; Rolf Wachter; Sinisa Dimkovic; Finn Waagstein; Götz Gelbrich; Hans-Dirk Düngen |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-12-2 |
Journal Detail:
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Title: Clinical biochemistry Volume: - ISSN: 1873-2933 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Inc. |
Affiliation:
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Zvezdara University Medical Center, Department of cardiology, Dimitrija Tucovica 161, 11 000 Belgrade, Serbia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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