Document Detail

Effect of beta-aminopropionitrile and hyaluronic acid on repair of collagenase-induced injury of the rabbit Achilles tendon.
MedLine Citation:
PMID:  11945005     Owner:  NLM     Status:  MEDLINE    
Collagenase was injected into the Achilles tendon of both hind legs of 10 clinically normal adult male New Zealand white rabbits. One month after induction of the injury, beta-aminoproprionitrile (BAPN) or hyaluronic acid (HA) was injected into the tendon core of the right hind leg of each rabbit, the left hind leg being left untreated. The treatment effects were evaluated by electron microscopy and analysis of the glycosaminoglycan (GAG) content of samples at 2 and 6 months post-treatment. At 2 months, collagen fibrils in tendons from both hind legs were relatively small in diameter, irregularly arranged, and interspersed with abundant active tenocytes as compared with those in normal tendon uninjured by collagenase. In the matrix, the amount of HA increased, but chondroitin-6-sulphate was eliminated. At 6 months, BAPN-treated tendons had small-diameter, regularly arranged collagen fibrils. HA-treated tendons, on the other hand, had large diameters, as well as regularly arranged collagen fibrils by comparison with non-treated tendon. The results suggest that HA, unlike BAPN, promoted healing.
E Yamamoto; D Hata; A Kobayashi; H Ueda; P Tangkawattana; M Oikawa; K Takehana
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of comparative pathology     Volume:  126     ISSN:  0021-9975     ISO Abbreviation:  J. Comp. Pathol.     Publication Date:    2002 Feb-Apr
Date Detail:
Created Date:  2002-04-11     Completed Date:  2002-10-18     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0102444     Medline TA:  J Comp Pathol     Country:  England    
Other Details:
Languages:  eng     Pagination:  161-70     Citation Subset:  IM    
Copyright Information:
Copyright Harcourt Publishers Ltd.
Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069-8501, Japan.
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MeSH Terms
Achilles Tendon / drug effects,  metabolism,  pathology*
Aminopropionitrile / administration & dosage,  therapeutic use*
Collagenases / pharmacology*
Disease Models, Animal
Extracellular Matrix / drug effects,  metabolism,  ultrastructure
Fibrillar Collagens / drug effects,  metabolism,  ultrastructure
Glycosaminoglycans / metabolism
Hyaluronic Acid / administration & dosage,  therapeutic use*
Injections, Intralesional
Microscopy, Electron, Scanning
Tendon Injuries / chemically induced,  drug therapy*,  metabolism
Wound Healing* / drug effects,  physiology
Reg. No./Substance:
0/Fibrillar Collagens; 0/Glycosaminoglycans; 151-18-8/Aminopropionitrile; 9004-61-9/Hyaluronic Acid; EC 3.4.24.-/Collagenases

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