Document Detail


Effect of beta-adrenoceptor blockade on exercise-induced plasma catecholamine concentration-heart rate response relationship.
MedLine Citation:
PMID:  2450237     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We examined the chronotropic and sympathoadrenal responses to a strenuous exercise in eight normal subjects receiving placebo and carteolol, a nonselective beta-adrenoceptor blocker. Plasma catecholamines were measured with high-performance liquid chromatography with electrochemical detection (HPLC-ECD). Mean plasma norepinephrine (NE) and epinephrine (E) concentrations attained at 0.5 and 2 min after exercise were significantly (p less than 0.001-0.05) greater in the carteolol trial than in the placebo trial and approached concentrations fairly similar to preexercise baseline values by 15 min after cessation of exercise in the two trials. The postexercise plasma NE and E concentration-chronotropic response relationships were shifted to the right in the carteolol as compared with the placebo phase. The maximal postexercise NE concentrations measured during the placebo trial correlated significantly with beta-adrenoceptor blockade (p less than 0.05, r = 0.74), whereas the relationship between E concentrations and beta-adrenoceptor blockade did not reach significant level in this small group of study subjects. The results suggest that beta-adrenoceptor blockade increases plasma concentrations of both NE and E during an earlier postexercise period and may cause a greater reflex sympathetic activation as compared with the adrenal response. However, the mechanism(s) remains unclear. Whether the exercise-induced NE rather than E would participate more predominantly in the chronotropic response to beta-adrenoceptor blockade requires further studies.
Authors:
A Ohnishi; A Minegishi; T Ishizaki
Related Documents :
18230697 - Dissociation between changes in muscle na+-k+-atpase isoform abundance and activity wit...
1332427 - Effect of oral contraceptives on plasma beta-endorphin and corticotropin at rest and du...
7438337 - Relationship of cardiac oxygen usage, adenosine content, and coronary resistance in dogs.
16344717 - The arg389gly beta1-adrenoceptor polymorphism does not affect cardiac effects of exerci...
20382667 - Basal and insulin-stimulated pyruvate dehydrogenase complex activation, glycogen synthe...
22684187 - Effect of nutritional interventions and resistance exercise on aging muscle mass and st...
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  10     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-04-18     Completed Date:  1988-04-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  667-74     Citation Subset:  IM    
Affiliation:
Division of Clinical Pharmacology, National Medical Center, Tokyo, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenergic beta-Antagonists / pharmacology*
Adult
Carteolol / pharmacology
Epinephrine / blood*
Heart Rate / drug effects*
Humans
Male
Norepinephrine / blood*
Physical Exertion*
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 51781-06-7/Carteolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A method to assess concomitant cardiac phosphodiesterase inhibition and positive inotropy.
Next Document:  Effects of capsaicin on nonadrenergic noncholinergic nerves in the guinea pig atria: role of calcito...