Document Detail

Effect of beta-adrenoceptor blockade on exercise-induced plasma catecholamine concentration-heart rate response relationship.
MedLine Citation:
PMID:  2450237     Owner:  NLM     Status:  MEDLINE    
We examined the chronotropic and sympathoadrenal responses to a strenuous exercise in eight normal subjects receiving placebo and carteolol, a nonselective beta-adrenoceptor blocker. Plasma catecholamines were measured with high-performance liquid chromatography with electrochemical detection (HPLC-ECD). Mean plasma norepinephrine (NE) and epinephrine (E) concentrations attained at 0.5 and 2 min after exercise were significantly (p less than 0.001-0.05) greater in the carteolol trial than in the placebo trial and approached concentrations fairly similar to preexercise baseline values by 15 min after cessation of exercise in the two trials. The postexercise plasma NE and E concentration-chronotropic response relationships were shifted to the right in the carteolol as compared with the placebo phase. The maximal postexercise NE concentrations measured during the placebo trial correlated significantly with beta-adrenoceptor blockade (p less than 0.05, r = 0.74), whereas the relationship between E concentrations and beta-adrenoceptor blockade did not reach significant level in this small group of study subjects. The results suggest that beta-adrenoceptor blockade increases plasma concentrations of both NE and E during an earlier postexercise period and may cause a greater reflex sympathetic activation as compared with the adrenal response. However, the mechanism(s) remains unclear. Whether the exercise-induced NE rather than E would participate more predominantly in the chronotropic response to beta-adrenoceptor blockade requires further studies.
A Ohnishi; A Minegishi; T Ishizaki
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  10     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-04-18     Completed Date:  1988-04-18     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  667-74     Citation Subset:  IM    
Division of Clinical Pharmacology, National Medical Center, Tokyo, Japan.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology*
Carteolol / pharmacology
Epinephrine / blood*
Heart Rate / drug effects*
Norepinephrine / blood*
Physical Exertion*
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 51781-06-7/Carteolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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