Document Detail

Effect of beta-adrenoceptor blockade on dipyridamole-induced myocardial asynergies in coronary artery disease.
MedLine Citation:
PMID:  1355629     Owner:  NLM     Status:  MEDLINE    
Twenty-one patients with angiographic evidence of significant coronary artery disease, and positive dipyridamole echocardiographic test results at basal condition and after 7 days of placebo treatment were prospectively studied to see whether beta blockade modifies the effects of dipyridamole echocardiographic testing on regional myocardial contractility. Patients were randomized to propranolol (120 mg/day) or placebo treatment in 3 divided doses for 7 days, after which each patient crossed over to the alternate regimen. Dipyridamole-echocardiographic testing was repeated at the end of each treatment. Propranolol abolished new mechanical signs of transient dipyridamole-induced ischemia (new wall motion abnormalities or an increase in degree of basal asynergies, or both) in 13 of 21 patients. The remaining 8 patients had positive results on dipyridamole echocardiographic testing after the propranolol treatment period. At basal conditions both heart rate and rate-pressure product were significantly reduced with propranolol; there was also a significant decrease in these parameters at peak dipyridamole infusion. At peak dipyridamole infusion heart rate and rate-pressure product were significantly lower in patients with negative than in those with positive echocardiographic test results after propranolol. Our data show that administration of beta blockade significantly reduces the development of transient dipyridamole-induced myocardial asynergies, the earliest markers of acute myocardial ischemia, detected with 2-dimensional echocardiography.
N Ferrara; G Longobardi; A Nicolino; D Acanfora; L Odierna; G Furgi; M Rossi; D Leosco; F Rengo
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of cardiology     Volume:  70     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-10-08     Completed Date:  1992-10-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  724-7     Citation Subset:  AIM; IM    
Cattedra di Geriatria, II Facoltà di Medicina e Chirurgia di Napoli, Naples, Italy.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology*
Coronary Angiography
Coronary Disease / epidemiology,  physiopathology,  ultrasonography*
Dipyridamole / diagnostic use*
Echocardiography / methods*
Hemodynamics / drug effects
Middle Aged
Myocardial Contraction / drug effects*
Propranolol / pharmacology*
Prospective Studies
Reproducibility of Results
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 525-66-6/Propranolol; 58-32-2/Dipyridamole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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