Document Detail

Effect of beta-adrenoceptor blockade on atrial natriuretic peptide levels during exercise in angina pectoris.
MedLine Citation:
PMID:  8095150     Owner:  NLM     Status:  MEDLINE    
The effects of epanolol (200 mg once daily) and diltiazem (60 mg three times daily) on the response of atrial natriuretic peptide (ANP) to exercise were investigated in a double-blind placebo-controlled crossover study in 16 patients with angina pectoris. Exercise tolerance as assessed by peak oxygen consumption was similar with all treatments. Peak heart rate (mean and 95% confidence intervals) was lower (P < 0.05) with epanolol (121 (115-130) beats min-1) than with diltiazem (137 (126-148) beats min-1) or placebo (141 (130-152) beats min-1). ANP did not change from resting values with placebo or diltiazem, but rose significantly (P < 0.05) with epanolol from 19.7 (13.0-29.8) pg ml-1 (geometric mean and 95% confidence intervals) during supine rest to 49.6 (33.7-73.0) pg ml-1 at peak exercise. Since ANP release is stimulated by atrial distension, patients with untreated angina may stop exercise before atrial dilatation occurs. With beta-adrenoceptor blockade, a reduction in peak heart rate may necessitate increased chamber volumes to maintain cardiac output, accounting for the rise in ANP.
M Riley; J S Elborn; G Onuoha; C Erwin; C Shaw; M M Khan; C F Stanford; D P Nicholls
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  35     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-02     Completed Date:  1993-04-02     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  209-12     Citation Subset:  IM    
Royal Victoria Hospital, Belfast, N. Ireland.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology*
Angina Pectoris / blood,  physiopathology*
Atrial Natriuretic Factor / blood*
Cardiac Output / drug effects
Diltiazem / administration & dosage,  pharmacology
Double-Blind Method
Exercise Test
Heart Rate / drug effects
Middle Aged
Oxygen Consumption / drug effects
Propanolamines / administration & dosage,  pharmacology
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Benzeneacetamides; 0/Propanolamines; 42399-41-7/Diltiazem; 85637-73-6/Atrial Natriuretic Factor; 86880-51-5/epanolol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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