| Effect of beta-adrenoceptor blockade on atrial natriuretic peptide levels during exercise in angina pectoris. | |
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MedLine Citation:
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PMID: 8095150 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of epanolol (200 mg once daily) and diltiazem (60 mg three times daily) on the response of atrial natriuretic peptide (ANP) to exercise were investigated in a double-blind placebo-controlled crossover study in 16 patients with angina pectoris. Exercise tolerance as assessed by peak oxygen consumption was similar with all treatments. Peak heart rate (mean and 95% confidence intervals) was lower (P < 0.05) with epanolol (121 (115-130) beats min-1) than with diltiazem (137 (126-148) beats min-1) or placebo (141 (130-152) beats min-1). ANP did not change from resting values with placebo or diltiazem, but rose significantly (P < 0.05) with epanolol from 19.7 (13.0-29.8) pg ml-1 (geometric mean and 95% confidence intervals) during supine rest to 49.6 (33.7-73.0) pg ml-1 at peak exercise. Since ANP release is stimulated by atrial distension, patients with untreated angina may stop exercise before atrial dilatation occurs. With beta-adrenoceptor blockade, a reduction in peak heart rate may necessitate increased chamber volumes to maintain cardiac output, accounting for the rise in ANP. |
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Authors:
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M Riley; J S Elborn; G Onuoha; C Erwin; C Shaw; M M Khan; C F Stanford; D P Nicholls |
Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 35 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1993 Feb |
Date Detail:
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Created Date: 1993-04-02 Completed Date: 1993-04-02 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 209-12 Citation Subset: IM |
Affiliation:
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Royal Victoria Hospital, Belfast, N. Ireland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
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pharmacology* Adult Aged Angina Pectoris / blood, physiopathology* Atrial Natriuretic Factor / blood* Benzeneacetamides* Cardiac Output / drug effects Diltiazem / administration & dosage, pharmacology Double-Blind Method Exercise* Exercise Test Female Heart Rate / drug effects Humans Male Middle Aged Oxygen Consumption / drug effects Propanolamines / administration & dosage, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists; 0/Benzeneacetamides; 0/Propanolamines; 42399-41-7/Diltiazem; 85637-73-6/Atrial Natriuretic Factor; 86880-51-5/epanolol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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