| Effect of beta-adrenergic suppression by propranolol on coronary collateral development in response to chronic coronary ischemia in dogs. | |
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MedLine Citation:
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PMID: 215339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute left circumflex coronary artery (LC) occlusion in conscious dogs caused marked ischemia in the myocardium supplied by the occluded artery, as judged by the radioactive microsphere technique for determining blood flow distribution. With the chest open, LC pressure distal to the occlusion fell to 21 +/- 1.9% of aortic pressure. By 8 weeks after gradual LC occlusion with an ameroid constrictor, collateral development had restored coronary blood flow distribution to near-normal under basal conditions and during pacing, at a heart rate of 200 beats/min. The only evidence for ischemia was in the subepicardium within the distribution of the unoccluded left anterior descending artery, which provided the extra collateral blood flow. Distal LC pressure was 70 +/- 1.7% of aortic pressure. Propranolol 160 mg orally every 6 hours for 8 weeks had no detectable effect on coronary collateral development, as judged by blood flow distribution or distal LC pressure. The only significant difference for the propranolol dogs was a slight transmural shift away from the subendocardium in the left anterior descending region. |
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Authors:
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W A Neill; V Nakornchai; J Oxendine; M S Paul |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Circulation Volume: 59 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1979 Feb |
Date Detail:
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Created Date: 1979-03-13 Completed Date: 1979-03-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 280-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Cardiac Pacing, Artificial Collateral Circulation / drug effects* Coronary Circulation / drug effects* Coronary Disease / physiopathology* Dogs Heart Rate / drug effects Injections, Intravenous Microspheres Propranolol / administration & dosage, pharmacology* Receptors, Adrenergic / drug effects* Receptors, Adrenergic, beta / drug effects* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Adrenergic; 0/Receptors, Adrenergic, beta; 525-66-6/Propranolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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