Document Detail

Effect of beta-adrenergic blockade on lung liquid secretion during fetal asphyxia.
MedLine Citation:
PMID:  2508494     Owner:  NLM     Status:  MEDLINE    
The hypothesis tested in this study was that beta-adrenergic stimulation is responsible for the inhibition of fetal lung liquid production during moderate fetal asphyxia. In chronically catheterized fetal sheep, net lung liquid production rates were measured over three consecutive periods: a control period, a period of reduced uterine blood flow (RUBF) or epinephrine infusion, and periods of RUBF or epinephrine infusion in the presence of the beta-adrenergic receptor antagonist propranolol. The net production rate of fetal lung liquid was decreased from a mean control value of 7.7 +/- 1.0 to 1.5 +/- 0.4 ml/h (P less than 0.001) by RUBF; the administration of propranolol had no further effect on these liquid production rates (1.1 +/- 0.5 ml/h). In other experiments epinephrine infusion reduced the net production rate of fetal lung liquid from a mean control value of 7.2 +/- 1.4 to 1.7 +/- 1.8 ml/h (P less than 0.025); the addition of propranolol reversed this inhibition (secretion rate 6.1 +/- 1.4 ml/h, P less than 0.005). We conclude that the inhibition of fetal lung liquid production induced by moderate fetal asphyxia does not solely result from catecholamine stimulation of pulmonary beta-receptors.
S B Hooper; R Harding
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  257     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-17     Completed Date:  1989-11-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R705-10     Citation Subset:  IM    
Department of Physiology, Monash University, Melbourne, Victoria, Australia.
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MeSH Terms
Asphyxia / embryology,  physiopathology*
Blood Pressure
Carbon Dioxide / blood
Epinephrine / pharmacology*
Fetal Blood / analysis*
Fetus / physiology
Heart Rate, Fetal*
Hydrogen-Ion Concentration
Lung / drug effects,  embryology,  secretion*
Oxygen / blood
Oxyhemoglobins / metabolism
Partial Pressure
Propranolol / pharmacology*
Regional Blood Flow
Uterus / blood supply
Reg. No./Substance:
0/Oxyhemoglobins; 124-38-9/Carbon Dioxide; 51-43-4/Epinephrine; 525-66-6/Propranolol; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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