Document Detail


Effect of benzene, toluene, xylene on the semen quality and the function of accessory gonad of exposed workers.
MedLine Citation:
PMID:  11341554     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects on semen and the function of accessory gonad of workers after short and long term exposure to benzene, toluene, and xylene were examined. The semen and blood of 24 married workers exposed to benzene, toluene, and xylene were collected. Routine sperm characteristic, acrosin activity, and Lactate dehydrogenase C4 (LDH-C4) relative activity were detected. The results showed that benzene, toluene, and xylene were found in the blood and semen of some ex-workers at workplaces where the air concentration of benzene, toluene, and xylene exceeded the maximum allowable concentration (MAC). No such solvents were detected in the blood and semen of workers of the control group. The sperm vitality and sperm motility decreased in the exposed workers. The mean acrosin activity, gamma-GT activity and LDH-C4 relative activity in the exposed workers were lower, and fructose concentration was higher than those in the control. There were negative correlations between sperm vitality, sperm activity, acrosin activity, or LDH-C4 relative activity and working history. These results suggest that the mixture of these solvents could affect the sperm and the function of accessory gonad. This might be one reason of the abnormal pregnancy outcome among the wives of workers exposed to benzene, toluene, and xylene.
Authors:
G Xiao; C Pan; Y Cai; H Lin; Z Fu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Industrial health     Volume:  39     ISSN:  0019-8366     ISO Abbreviation:  Ind Health     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-05-08     Completed Date:  2001-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985065R     Medline TA:  Ind Health     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  206-10     Citation Subset:  IM    
Affiliation:
Institute of Occupational Medicine, Ningbo Municipal Centers for Disease Control and Prevention, PR China.
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MeSH Terms
Descriptor/Qualifier:
Acrosin / metabolism
Adult
Benzene / adverse effects*,  analysis*
Case-Control Studies
Chi-Square Distribution
Humans
Male
Maximum Allowable Concentration
Occupational Exposure*
Semen / drug effects*,  physiology*
Sperm Count
Sperm Motility / drug effects
Testis / drug effects,  physiology
Toluene / adverse effects*,  analysis*,  blood
Xylenes / adverse effects*,  analysis*,  blood
Chemical
Reg. No./Substance:
0/Xylenes; 108-88-3/Toluene; 71-43-2/Benzene; EC 3.4.21.10/Acrosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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