Document Detail

Effect of benidipine hydrochloride, a dihydropyridine-type calcium antagonist, on the function of mouse osteoblastic cells.
MedLine Citation:
PMID:  9576986     Owner:  NLM     Status:  MEDLINE    
The effects of benidipine hydrochloride (BD), a dihydropyridine-type calcium antagonist, on the growth and alkaline phosphatase (ALPase) activity were studied in cultures of mouse osteoblastic cells. BD (0.1-10 nM) increased the ALPase activity of osteoblastic cells and reduced cell proliferation incubated for 48 h. This reduction of cell growth did not appear to be due to cell death. On the other hand, nifedipine and amlodipine (1 nM) had no effect. BD (0.1-10 nM) enhanced the effects of 1,25(OH)2D3 on osteoblastic cells, the decreased cell growth and increased ALPase activity. These findings suggest that BD regulates the growth and differentiation of osteoblasts and stimulates the function of these cells as well as 1,25(OH)2D3.
N Kosaka; M Uchii
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Calcified tissue international     Volume:  62     ISSN:  0171-967X     ISO Abbreviation:  Calcif. Tissue Int.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-06-16     Completed Date:  1998-06-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7905481     Medline TA:  Calcif Tissue Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  554-6     Citation Subset:  IM; S    
General Pharmacology, Drug Discovery Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd., 1188 Shimotogari, Nagaizumi-cho, Sunto-gun, Shizuoka-ken, 411 Japan.
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MeSH Terms
Alkaline Phosphatase / metabolism
Calcitriol / pharmacology
Calcium / metabolism
Calcium Channel Blockers / pharmacology*
Cells, Cultured
Dihydropyridines / pharmacology*
Osteoblasts / drug effects*,  metabolism
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Dihydropyridines; 105979-17-7/benidipine; 32222-06-3/Calcitriol; 7440-70-2/Calcium; EC Phosphatase

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