| Effect of bee venom on transforming growth factor-beta1-treated hepatocytes. | |
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MedLine Citation:
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PMID: 20075187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bee venom (BV) has been used as treatment against a wide variety of ailments, including inflammatory diseases. Various studies have demonstrated anti-inflammatory and anticancer effects of BV. Transforming growth factor (TGF)-beta1 induces hepatocyte apoptosis via the mitochondrial permeability transition. However, there is no evidence or information regarding the antiapoptotic effect of BV on hepatocytes. The authors investigated the antiapoptotic effect of BV on TGF-beta1-treated hepatocytes. The results showed significant protection from DNA damage by BV treatment compared to corresponding TGF-beta1-treated hepatocytes without BV. BV suppressed TGF-beta1-induced activation of the bcl-2 family and caspase family of proteins, which resulted in inhibition of poly ADP-ribose polymerase (PARP) cleavage. Furthermore, BV is not cytotoxic in the low concentrations used in this study. Low concentrations of BV potently suppress the apoptotic response in TGF-beta1-treated hepatocytes; therefore, BV may have therapeutic potential for the treatment of liver diseases. |
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Authors:
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Jung-Hyun Park; Kyung-Hyun Kim; Soo-Jung Kim; Woo-Ram Lee; Kwang-Gill Lee; Ji-Hyun Park; Kwan-Kyu Park |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of toxicology Volume: 29 ISSN: 1092-874X ISO Abbreviation: Int. J. Toxicol. Publication Date: 2010 Jan-Feb |
Date Detail:
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Created Date: 2010-01-15 Completed Date: 2010-03-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9708436 Medline TA: Int J Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 49-56 Citation Subset: IM |
Affiliation:
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Department of Rehabilitation Medicine, Eulji University Hospital, Daejeon, South Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / drug effects Bee Venoms / pharmacology* Cell Line Cell Survival / drug effects DNA Fragmentation / drug effects Dose-Response Relationship, Drug Formazans / metabolism Hepatocytes / drug effects*, metabolism, pathology Mice Poly(ADP-ribose) Polymerases / antagonists & inhibitors, drug effects Protective Agents / pharmacology* Proto-Oncogene Proteins c-bcl-2 / drug effects, metabolism Tetrazolium Salts / metabolism Transforming Growth Factor beta / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Bee Venoms; 0/Formazans; 0/Protective Agents; 0/Proto-Oncogene Proteins c-bcl-2; 0/Tetrazolium Salts; 0/Transforming Growth Factor beta; 23305-68-2/MTT formazan; EC 2.4.2.30/Poly(ADP-ribose) Polymerases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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