Document Detail

Effect of basic fibroblast growth factor, trafermin, on entero-related fistulae, report of two cases.
MedLine Citation:
PMID:  17591067     Owner:  NLM     Status:  MEDLINE    
Entero-related fistulae are often intractable. Recently, growth factors were generally in sight with the development of regenerative medicine. Basic fibroblast growth factor (bFGF) possesses potent angiogenic activity. In Japan, recombinant bFGF, also known as Trafermin, has been administered for intractable skin ulcer for its strong effect on tissue granulation. Here, we report the effect of bFGF for entero-related fistulae. Two intractable cases were treated by applying bFGF in the fistulae after performing the enterostomy. Case 1: Postoperative intractable vesicorectal fistula was treated by bFGF. 82 days later, fistula was closed. Case 2: Colonic perforation due to ischemic colitis was treated. 37 days after treatment, fistula was closed. In conclusion, in the treatment of the intractable entero-related fistulae, Trafermin was useful for healing the fistulae.
Satoru Yamaguchi; Takayuki Asao; Junichi Nakamura; Kaori Tsuboi; Soichi Tsutsumi; Hiroyuki Kuwano
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  54     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2007 Apr-May
Date Detail:
Created Date:  2007-06-26     Completed Date:  2007-08-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  803-5     Citation Subset:  IM    
Department of General Surgical Science, Gunma University Graduate School, Graduate School of Medicine, 39-22, Showa-machi 3-chome, Maebashi, Gunma 371-8511, Japan.
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MeSH Terms
Fibroblast Growth Factors / therapeutic use*
Intestinal Perforation / drug therapy*,  radiography
Middle Aged
Peptide Fragments / therapeutic use*
Rectal Fistula / drug therapy*,  radiography
Urinary Bladder* / radiography
Reg. No./Substance:
0/Peptide Fragments; 131094-16-1/trafermin; 62031-54-3/Fibroblast Growth Factors

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