Document Detail


Effect based monitoring of seasonal ambient air exposures in Australia sampled by PUF passive air samplers.
MedLine Citation:
PMID:  21552507     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
There has been relatively little bioanalytical effect based monitoring conducted using samples derived from polyurethane foam (PUF) passive air samplers. Combining these techniques may provide a more convenient and cost effective means of monitoring the potential for biological effects resulting from exposure to complex mixtures in a range of scenarios. Seasonal polycyclic aromatic hydrocarbon (PAH) levels were monitored at sites around Australia using direct chemical analysis. In addition, both indirect acting genotoxicity (umuC assay) and aryl hydrocarbon receptor (AhR) activity (chemically activated fluorescent gene expression [CAFLUX assay]), which are effects potentially relevant to subsequent carcinogenesis for these compounds, were measured. The levels of PAHs as well as genotoxicity and AhR activity were all higher in winter compared to summer and for sites in urban capital cities compared to other locations. Statistically significant relationships were found between the levels of PAHs and both genotoxicity and AhR activity. The dominant contributors to the total AhR activity, were found to be for compounds which are not resistant to H(2)SO(4)/silica gel treatment and were relatively rapidly metabolised that is consistent with a PAH type response. Relative potency estimates for individual PAHs determined for the first time on the CAFLUX assay were used to estimate the proportion of total AhR activity (≤ 3.0%) accounted by PAHs monitored. Observed responses are thus largely due to non-quantified AhR active compounds.
Authors:
Karen Kennedy; Miroslava Macova; Michael E Bartkow; Darryl W Hawker; Bin Zhao; Michael S Denison; Jochen F Mueller
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Atmospheric pollution research     Volume:  1     ISSN:  1309-1042     ISO Abbreviation:  -     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2011-5-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101554506     Medline TA:  -     Country:  -    
Other Details:
Languages:  ENG     Pagination:  50-58     Citation Subset:  -    
Affiliation:
The University of Queensland, Entox (The National Research Centre for Environmental Toxicology), Brisbane QLD 4108, Australia.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
P42 ES004699-23//NIEHS NIH HHS

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