| Effect of bamiphylline on tracheobronchial mucus clearance in subjects with smokers' simple chronic bronchitis. | |
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MedLine Citation:
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PMID: 7716349 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A double-blind study versus placebo was performed to assess the effect of bamiphylline, a new xanthylic derivative, on tracheobronchial mucus clearance (TBMC) in smokers with simple chronic bronchitis and impaired mucus clearance as compared to normal controls. Twenty patients were enrolled and divided into two randomized groups. The first group was treated with bamiphylline (600 mg b.d.) for 15 days, while the second group received placebo with the same oral dosage regimen. Complete clinical-functional examinations were made before and after the test period to establish the effects of treatment. At the end of the study, only the group treated with bamiphylline showed a net increase in mucus clearance (mean radioaerosol elimination 28 +/- 7% before treatment and 38 +/- 11% after treatment; p < 0.01) and an improvement in the clinical score and pulmonary function parameters, in particular the residual volume (RV = 3.41 +/- 0.75 liters before treatment and 2.7 +/- 0.6 after treatment; p < 0.01) and the forced expiratory volume at 1 s (FEV1 = 2.37 +/- 0.7 liters before treatment and 2.88 +/- 0.5 after treatment; p < 0.05). No side effects or adverse reactions that could be attributed to the study drug were observed. |
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Authors:
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T Todisco; S Baglioni; E Amir; R Palumbo |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Respiration; international review of thoracic diseases Volume: 62 ISSN: 0025-7931 ISO Abbreviation: Respiration Publication Date: 1995 |
Date Detail:
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Created Date: 1995-05-15 Completed Date: 1995-05-15 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0137356 Medline TA: Respiration Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 16-20 Citation Subset: IM |
Affiliation:
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Pulmonary Division, R. Silverstrini Hospital, Perugia, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Bronchitis / drug therapy*, etiology, physiopathology Bronchodilator Agents / administration & dosage, therapeutic use* Chronic Disease Double-Blind Method Female Humans Male Middle Aged Mucociliary Clearance / drug effects* Respiratory Function Tests Smoking / adverse effects, physiopathology* Theophylline / administration & dosage, analogs & derivatives*, therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Bronchodilator Agents; 2016-63-9/bamifylline; 58-55-9/Theophylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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