Document Detail


Effect of bamiphylline on tracheobronchial mucus clearance in subjects with smokers' simple chronic bronchitis.
MedLine Citation:
PMID:  7716349     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A double-blind study versus placebo was performed to assess the effect of bamiphylline, a new xanthylic derivative, on tracheobronchial mucus clearance (TBMC) in smokers with simple chronic bronchitis and impaired mucus clearance as compared to normal controls. Twenty patients were enrolled and divided into two randomized groups. The first group was treated with bamiphylline (600 mg b.d.) for 15 days, while the second group received placebo with the same oral dosage regimen. Complete clinical-functional examinations were made before and after the test period to establish the effects of treatment. At the end of the study, only the group treated with bamiphylline showed a net increase in mucus clearance (mean radioaerosol elimination 28 +/- 7% before treatment and 38 +/- 11% after treatment; p < 0.01) and an improvement in the clinical score and pulmonary function parameters, in particular the residual volume (RV = 3.41 +/- 0.75 liters before treatment and 2.7 +/- 0.6 after treatment; p < 0.01) and the forced expiratory volume at 1 s (FEV1 = 2.37 +/- 0.7 liters before treatment and 2.88 +/- 0.5 after treatment; p < 0.05). No side effects or adverse reactions that could be attributed to the study drug were observed.
Authors:
T Todisco; S Baglioni; E Amir; R Palumbo
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  62     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1995  
Date Detail:
Created Date:  1995-05-15     Completed Date:  1995-05-15     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  16-20     Citation Subset:  IM    
Affiliation:
Pulmonary Division, R. Silverstrini Hospital, Perugia, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aged
Bronchitis / drug therapy*,  etiology,  physiopathology
Bronchodilator Agents / administration & dosage,  therapeutic use*
Chronic Disease
Double-Blind Method
Female
Humans
Male
Middle Aged
Mucociliary Clearance / drug effects*
Respiratory Function Tests
Smoking / adverse effects,  physiopathology*
Theophylline / administration & dosage,  analogs & derivatives*,  therapeutic use
Treatment Outcome
Chemical
Reg. No./Substance:
0/Bronchodilator Agents; 2016-63-9/bamifylline; 58-55-9/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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