| Effect of baicalein from Scutellaria baicalensis on prevention of noise-induced hearing loss. | |
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MedLine Citation:
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PMID: 20004700 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Noise-induced hearing loss (NIHL) has been thought to primarily involve damage to the sensory hair cells of the cochlea via mechanical and metabolic mechanisms. This study examined the effects of baicalin, baicalein, and Scutellaria baicalensis (SB) extract against NIHL in a mouse model. Mice received oral treatment with SB, baicalin, baicalein beginning 30 min prior to noise exposure and continuing once daily throughout the study. Hearing threshold shift was assessed by auditory brain stem responses for 35 days following noise exposure. Central auditory function was evaluated by auditory middle latency responses. Cochlear function was determined based on transient evoked otoacoustic emissions. SB significantly reduced threshold shift, central auditory function damage, and cochlear function deficits, suggesting that SB may protect auditory function in NIHL and that the active constituent may be a flavonoid, baicalein. |
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Authors:
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Tong Ho Kang; Bin Na Hong; Channy Park; Se Young Kim; Raekil Park |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-11 |
Journal Detail:
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Title: Neuroscience letters Volume: 469 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-02-01 Completed Date: 2010-04-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 298-302 Citation Subset: IM |
Copyright Information:
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(c) 2009 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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College of Life Sciences, Kyung Hee University, Gyeonggi 446-701, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation Animals Auditory Perception / drug effects Auditory Threshold / drug effects Cochlea / drug effects Disease Models, Animal Dose-Response Relationship, Drug Flavanones / administration & dosage, chemistry, pharmacology* Flavonoids / administration & dosage, chemistry, pharmacology* Hearing Loss, Noise-Induced / drug therapy*, prevention & control* Hearing Tests Male Mice Mice, Inbred ICR Neuroprotective Agents / administration & dosage, chemistry, pharmacology* Plant Extracts / administration & dosage, chemistry, pharmacology* Scutellaria baicalensis / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Flavanones; 0/Flavonoids; 0/Neuroprotective Agents; 0/Plant Extracts; 0/Scutellaria baicalensis extract; 21967-41-9/baicalin; 491-67-8/baicalein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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