Document Detail


Effect of baicalein from Scutellaria baicalensis on prevention of noise-induced hearing loss.
MedLine Citation:
PMID:  20004700     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Noise-induced hearing loss (NIHL) has been thought to primarily involve damage to the sensory hair cells of the cochlea via mechanical and metabolic mechanisms. This study examined the effects of baicalin, baicalein, and Scutellaria baicalensis (SB) extract against NIHL in a mouse model. Mice received oral treatment with SB, baicalin, baicalein beginning 30 min prior to noise exposure and continuing once daily throughout the study. Hearing threshold shift was assessed by auditory brain stem responses for 35 days following noise exposure. Central auditory function was evaluated by auditory middle latency responses. Cochlear function was determined based on transient evoked otoacoustic emissions. SB significantly reduced threshold shift, central auditory function damage, and cochlear function deficits, suggesting that SB may protect auditory function in NIHL and that the active constituent may be a flavonoid, baicalein.
Authors:
Tong Ho Kang; Bin Na Hong; Channy Park; Se Young Kim; Raekil Park
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-11
Journal Detail:
Title:  Neuroscience letters     Volume:  469     ISSN:  1872-7972     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-04-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  298-302     Citation Subset:  IM    
Copyright Information:
(c) 2009 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
College of Life Sciences, Kyung Hee University, Gyeonggi 446-701, Republic of Korea.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Animals
Auditory Perception / drug effects
Auditory Threshold / drug effects
Cochlea / drug effects
Disease Models, Animal
Dose-Response Relationship, Drug
Flavanones / administration & dosage,  chemistry,  pharmacology*
Flavonoids / administration & dosage,  chemistry,  pharmacology*
Hearing Loss, Noise-Induced / drug therapy*,  prevention & control*
Hearing Tests
Male
Mice
Mice, Inbred ICR
Neuroprotective Agents / administration & dosage,  chemistry,  pharmacology*
Plant Extracts / administration & dosage,  chemistry,  pharmacology*
Scutellaria baicalensis / chemistry
Chemical
Reg. No./Substance:
0/Flavanones; 0/Flavonoids; 0/Neuroprotective Agents; 0/Plant Extracts; 0/Scutellaria baicalensis extract; 21967-41-9/baicalin; 491-67-8/baicalein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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