| Effect of autonomic blockade on pressor responses to vasopressin in pregnant rats. | |
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MedLine Citation:
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PMID: 7977537 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: We tested the hypothesis that gestational changes in reflex neural control of the heart and vasculature contribute to altered cardiovascular responses to vasopressin during pregnancy. STUDY DESIGN: Changes in mean arterial pressure, cardiac output, total peripheral resistance, and heart rate were measured in response to constant infusion of arginine vasopressin (0.15 to 2.5 mU/kg/min) in conscious pregnant and virgin rats (n = 9) with total autonomic blockade plus restoration of baseline hemodynamics by norepinephrine infusion. RESULTS: Resting cardiac output was 40% higher and total peripheral resistance 30% lower in pregnant animals (p < 0.01). Constant infusion of arginine vasopressin evoked equivalent changes in mean arterial pressure in both groups, but the respective contributions of cardiac output and total peripheral resistance to mean arterial pressure differed between groups. Cardiac output was unchanged and the increase in total peripheral resistance was significantly blunted in pregnant vs virgin rats during arginine vasopressin infusion. Control data in nonblocked revealed similar pressor responses to arginine vasopressin in gravid compared with virgin rats but no differences in the contributions of cardiac output and total peripheral resistance to the change in mean arterial pressure. CONCLUSION: These findings suggest that neural modulation of arginine vasopressin-induced hypertension is altered during pregnancy and are consistent with a reduction in intrinsic vascular sensitivity to arginine vasopressin during gestation. |
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Authors:
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T Hines; M D Lindheimer; W M Barron |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 171 ISSN: 0002-9378 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1994-12-21 Completed Date: 1994-12-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1296-302 Citation Subset: AIM; IM |
Affiliation:
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Department of Obstetrics and Gynecology, University of Chicago, Illinois. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine Vasopressin / pharmacology* Autonomic Nerve Block* Blood Pressure / drug effects* Cardiac Output / drug effects Cardiovascular System / drug effects Female Hemodynamics Pregnancy Pregnancy, Animal / physiology* Rats Rats, Sprague-Dawley Reference Values Reflex / physiology |
| Grant Support | |
ID/Acronym/Agency:
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1F32HL08521/HL/NHLBI NIH HHS; HD24498/HD/NICHD NIH HHS; HL34731/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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113-79-1/Arginine Vasopressin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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