Document Detail

Effect of autologous platelet-rich plasma on the repair of full-thickness articular defects in rabbits.
MedLine Citation:
PMID:  22918398     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the effect of autologous platelet-rich plasma on the repair of full-thickness articular cartilage lesions in immature rabbits. To that end, the samples were studied using macroscopic, microscopic and biomechanical techniques.
METHODS: Twenty-four 11-week-old New Zealand rabbits were divided into two groups based on the treatment (physiological saline serum PCB, autologous platelet-rich plasma PRP). Cartilage lesions were drilled in medial femoral condyle of these rabbits. Other 12 rabbits were under the same conditions, but they did not suffer any lesion and treatment (control group CTR). The three groups were divided into two subgroups, depending on the age at the time of killing (16 and 19 weeks old).
RESULTS: The CTR group showed the best possible value in the macroscopic and microscopic evaluation. Meanwhile, the PCB and PRP group values were lower than the CTR group values, at two times of the study, but similar to each other at 19 weeks. In the biomechanical study, at 16 weeks, the CTR and PCB groups behaved similarly, with values above PRP group values, while at 19 weeks, CTR group showed higher values than PCB and PRP groups, and there were no differences between these values.
CONCLUSIONS: The evolution of the tissue treated with autologous PRP showed a positive tendency over time, while the PCB group was negative. Nevertheless, at 19 weeks of age, the PRP treatment did not show better results than the PCB, both showing the characteristics of fibrocartilaginous tissue. Likewise, none of the two treatments produced a repair tissue as the healthy cartilage.
Claudio Iván Serra; Carme Soler; Jose M Carrillo; Jose M Carillo; Joaquín J Sopena; J Ignacio Redondo; Ramón Cugat
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-24
Journal Detail:
Title:  Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA     Volume:  21     ISSN:  1433-7347     ISO Abbreviation:  Knee Surg Sports Traumatol Arthrosc     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-22     Completed Date:  2014-03-26     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  9314730     Medline TA:  Knee Surg Sports Traumatol Arthrosc     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1730-6     Citation Subset:  IM    
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MeSH Terms
Biomechanical Phenomena
Blood Transfusion, Autologous
Cartilage, Articular / injuries*,  pathology*,  surgery
Femur / injuries,  surgery
Platelet-Rich Plasma*
Erratum In:
Knee Surg Sports Traumatol Arthrosc. 2014 Jul;22(7):1710
Note: Carillo, Jose M [corrected to Carrillo, Jose M]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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