Document Detail

Effect of autologous epidermal cell suspension transplantation in chronic nonhealing wounds: a pilot study.
MedLine Citation:
PMID:  20100406     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chronic nonhealing wounds are difficult to manage. Various substances are being used to heal these wounds. We sought to observe the effects of autologous epidermal cell suspension dressings on chronic nonhealing ulcers.
METHODS: We enrolled patients of the wound clinic at University Hospital, Varanasi, India, with nonhealing wounds of more than 6 weeks' duration. We treated the wound beds with sterile dressings and antibiotics until the swab cultures became sterile. We prepared autologous epidermal cell suspensions from skin grafts and used them on the ulcer beds along with Vaseline gauze dressings. Follow-up visits with patients occurred weekly for assessment of wound healing and other changes.
RESULTS: Fifteen patients enrolled in our study. Of these, 6 patients had completely healed at 12 weeks, 1 patient at 16 weeks and 2 patients at 20 weeks after treatment. We observed a slow healing response in 6 patients, of whom 1 patient had healed completely at 32 weeks and another at 48 weeks. One patient needed skin grafting, and 3 patients were lost to follow-up.
CONCLUSION: Autologous noncultured epidermal cell suspension transplantation seems to be an effective, simple and time-saving method to treat chronic nonhealing wounds.
Vijay K Shukla; Satyendra K Tiwary; Shruti Barnwal; Anil K Gulati; Shyam S Pandey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of surgery. Journal canadien de chirurgie     Volume:  53     ISSN:  1488-2310     ISO Abbreviation:  Can J Surg     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-26     Completed Date:  2010-02-23     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0372715     Medline TA:  Can J Surg     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  6-10     Citation Subset:  IM    
Department of General Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi - 221 005, India.
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MeSH Terms
Chronic Disease
Keratinocytes / transplantation*
Middle Aged
Pilot Projects
Skin Ulcer / microbiology,  therapy*
Staphylococcal Skin Infections / therapy
Tissue Culture Techniques
Transplantation, Autologous
Wound Healing / physiology*
Young Adult
Comment In:
Can J Surg. 2010 Dec;53(6):E7; author reply E7   [PMID:  21092426 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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