Document Detail

Effect of atropine and terbutaline on motor activity of the continent caecal reservoir for urine.
MedLine Citation:
PMID:  2540869     Owner:  NLM     Status:  MEDLINE    
The effects of muscarinic receptor blockade (atropine) and of beta-adrenoceptor stimulation (terbutaline) on the motor activity of the continent caecal reservoir for urine were studied in 12 patients during continuous filling of the reservoir. Basal pressure was low at high level filling, but pressure waves with amplitudes of 40 to 50 cm H2O occurred every other minute. The reservoir's functional adaptation, revealed as a diminished amplitude of pressure waves and evident soon after its construction, remained stable at long-term follow-up. Subcutaneously injected atropine or terbutaline did not influence the basal pressure but increased the volume at which the first pressure wave appeared and decreased the wave amplitude and frequency at high filling levels. Intra-reservoir instillation of these drugs did not alter the dynamic behaviour of the reservoir. In selected patients, orally administered anticholinergic drugs or beta 2-adrenoceptor agonists may be useful in the management of hyperactivity in a colonic segment used as a continent reservoir or bladder substitute.
W Månsson; H Hedlund; K E Andersson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of urology     Volume:  63     ISSN:  0007-1331     ISO Abbreviation:  Br J Urol     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-06-15     Completed Date:  1989-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  15740090R     Medline TA:  Br J Urol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  375-8     Citation Subset:  IM    
Department of Urology, University Hospital, Lund, Sweden.
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MeSH Terms
Atropine / pharmacology*
Cecum / drug effects*,  physiopathology,  surgery
Gastrointestinal Motility / drug effects*
Middle Aged
Receptors, Adrenergic, beta / drug effects
Receptors, Muscarinic / drug effects
Terbutaline / pharmacology*
Urinary Diversion*
Reg. No./Substance:
0/Receptors, Adrenergic, beta; 0/Receptors, Muscarinic; 23031-25-6/Terbutaline; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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