Document Detail

Effect of atropine on food-stimulated gastrin release after truncal vagotomy in man.
MedLine Citation:
PMID:  873115     Owner:  NLM     Status:  MEDLINE    
Studies have been performed on man after truncal vagotomy to ascertain the effect of 1.2 mg of atropine sulfate on basal and postprandial immunoreactive gastrin. Atropine had no effect on basal gastrin, but it caused a significant increase in both the peak postprandial gastrin (135 to 240 pg per ml without the 139 to 308 pg per ml with atropine) and the integrated gastrin response (10.2 and 15.5 ng-min per ml over 2 hr respectively). This indicates that vagal integrity is not essential for the enhancement of the gastrin response by atropine and implies a direct effect on the antral gastrin cell.
J Hansky; R W King
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  73     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-08-25     Completed Date:  1977-08-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-6     Citation Subset:  AIM; IM    
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MeSH Terms
Atropine / pharmacology*
Duodenal Ulcer / physiopathology,  surgery*
Gastric Mucosa / secretion*
Gastrins / secretion*
Middle Aged
Reg. No./Substance:
0/Gastrins; 51-55-8/Atropine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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