Document Detail

Effect of atrial antitachycardia pacing treatments in patients with an atrial defibrillator: randomised study comparing subthreshold and nominal pacing outputs.
MedLine Citation:
PMID:  11997413     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To assess the true efficacy of antitachycardia pacing on spontaneous persistent atrial fibrillation in patients with an implanted atrial defibrillator, by comparing the effects of nominal pacing treatment with subthreshold pacing treatment.
DESIGN: The effects of antitachycardia pacing and burst 50 Hz atrial pacing on spontaneous atrial arrhythmias were evaluated six months after implantation of a Medtronic Jewel AF((R)) atrial defibrillator.
SETTING: Cardiology department in a district general hospital.
PATIENTS: 15 patients with persistent atrial fibrillation.
INTERVENTIONS: Patients were randomised to either "nominal" output pacing treatment or surface ECG and endocardial electrogram proven subthreshold "sham" pacing treatment for three months, and then crossed over to the alternative treatment for a further three months.
RESULTS: During the nominal output phase, 31 episodes of atrial fibrillation were treated with 53 bursts of 50 Hz pacing, 98 sequences of ramp atrial pacing, and 61 sequences of burst atrial pacing. Atrial fibrillation was not pace terminated during any episode. Thirty one episodes of atrial tachycardia were treated with 19 bursts of 50 Hz atrial pacing, 103 sequences of ramp atrial pacing, and 38 sequences of burst atrial pacing. Termination of atrial tachycardia was observed in 17 episodes. During the "sham" pacing period, no episodes were terminated by any pacing treatment.
CONCLUSION: Atrial antitachycardia pacing treatments are ineffective at terminating persistent atrial fibrillation but may be useful in terminating episodes of atrial tachycardia or flutter, thus reducing the burden of arrhythmia.
A R J Mitchell; P A R Spurrell; L Cheatle; N Sulke
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  87     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-08     Completed Date:  2002-06-06     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  433-7     Citation Subset:  AIM; IM    
Department of Cardiology, Eastbourne General Hospital, Eastbourne, East Sussex, UK.
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MeSH Terms
Aged, 80 and over
Atrial Fibrillation / therapy*
Cardiac Pacing, Artificial / methods*
Death, Sudden, Cardiac / prevention & control
Defibrillators, Implantable*
Middle Aged
Risk Factors
Survival Analysis
Tachycardia / therapy
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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