Document Detail


Effect of atorvastatin on exercise-induced myocardial ischemia in patients with stable angina pectoris.
MedLine Citation:
PMID:  14609594     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate whether marked and sustained lipid-lowering in subjects with stable angina pectoris and dyslipidemia reduces exercise-induced myocardial ischemia, 17 subjects were treated with dose-adjusted atorvastatin over 1 year and underwent serial evaluation of exercise electrocardiographic ischemic parameters, serum biomarkers, and brachial artery endothelial function. Endothelial function improved progressively and C-reactive protein, P-selectin, and tissue plasminogen activator inhibitor levels decreased, but there was no decrease in exercise electrocardiographic ischemia.
Authors:
Peter Bogaty; Gilles R Dagenais; Paul Poirier; Luce Boyer; Lucie Auclair; Guylaine Pépin; Jean Jobin; Marie Arsenault
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of cardiology     Volume:  92     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-11     Completed Date:  2004-02-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1192-5     Citation Subset:  AIM; IM    
Affiliation:
Quebec Heart Institute, Laval Hospital, Ste-Foy, Quebec, Canada. peter.Bogaty@med.ulaval.ca
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MeSH Terms
Descriptor/Qualifier:
Aged
Angina, Unstable / complications,  drug therapy*,  physiopathology
Dose-Response Relationship, Drug
Drug Administration Schedule
Exercise Test / adverse effects*
Female
Heptanoic Acids / therapeutic use*
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Hyperlipidemias / complications,  drug therapy,  physiopathology
Male
Middle Aged
Myocardial Ischemia / drug therapy*,  etiology*,  physiopathology
Pyrroles / therapeutic use*
Chemical
Reg. No./Substance:
0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 110862-48-1/atorvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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