| Effect of aspirin and indomethacin on exercise-induced changes in blood pressure and limb blood flow in normal volunteers. | |
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MedLine Citation:
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PMID: 3986859 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To evaluate the possible role of prostaglandins in exercise-induced changes in blood pressure and limb blood flow we have compared the effects of aspirin and indomethacin in a double-blind placebo controlled study in a group of normal volunteers. Nine men undertook treadmill exercise after pretreatment with placebo, aspirin and indomethacin. Indomethacin caused a greater increase in systolic blood pressure during exercise than aspirin (p less than 0.05) and a smaller fall in diastolic pressure than either placebo or aspirin (p less than 0.02 and p less than 0.01). Compared with placebo both aspirin and indomethacin attenuated to a similar degree the increase in calf blood flow (p less than 0.05 and p less than 0.03) and the changes in forearm blood flow following exercise. These results suggest that although aspirin and indomethacin both inhibit prostaglandin production they have different effects on exercise-induced changes in blood pressure. They have, however, similar effects on limb blood flow. |
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Authors:
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A J Cowley; K Stainer; J M Rowley; R G Wilcox |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Cardiovascular research Volume: 19 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1985 Mar |
Date Detail:
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Created Date: 1985-06-07 Completed Date: 1985-06-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 177-80 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aspirin / pharmacology* Blood Pressure / drug effects* Double-Blind Method Extremities / blood supply* Forearm / blood supply Humans Indomethacin / pharmacology* Leg / blood supply Male Physical Exertion* Regional Blood Flow / drug effects Time Factors |
| Chemical | |
Reg. No./Substance:
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50-78-2/Aspirin; 53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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